干细胞治疗可以降低慢性支气管炎患者的T细胞亡,但不能降低肺气
Emel Eryüksel1, Zeynep Tunca2, Zeynep Mercancı1
1Pulmonary and Critical Care, Faculty of Medicine, Marmara University, Turkey.
Tissue & cell
|July 10, 2024
概括
介质干细胞 (MSC) 治疗显示出降低慢性阻塞性肺病 (COPD) 中淋巴细胞亡的潜力. 响应因COPD表型而异,这表明定制干细胞治疗可能是有益的.
科学领域:
- 再生医学是一种再生医学.
- 肺部医学 肺部医学
- 免疫学 免疫学 免疫学
背景情况:
- 慢性阻塞性肺病 (COPD) 是一种广泛的,可预防的呼吸道疾病.
- 介质干细胞 (MSC) 治疗正在研究肺细胞再生和COPD的功能恢复.
- 了解MSC与COPD患者细胞的相互作用,对于治疗的发展至关重要.
研究的目的:
- 研究MSCs对来自各种COPD表型的外周血液单核细胞 (PBMCs) 的差异性影响.
- 将共同培养中的MSC反应与患有喘-COPD重叠综合征 (ACOS),肺气和慢性支气管炎的患者的PBMC进行比较,并与对照组进行比较.
主要方法:
- 从COPD患者 (ACOS,肺气,慢性支气管炎) 和健康对照中分离出周围血液单核细胞 (PBMC).
- PBMCs与牙毛囊衍生的介质干细胞 (MSCs) 共同培养.
- 在共同培养的细胞中评估了亡率和淋巴细胞活力.
主要成果:
- 与MSCs共同培养表明,在COPD表型中对淋巴细胞亡有不同的影响.
- 慢性支气管炎组最初显示最低的淋巴细胞活力 (p<0.01).
- 在所有组中,MSC引入显著改善了淋巴细胞活力,除了肺气,在慢性支气管炎组中观察到的最大增强 (p<0.05).
结论:
- 中介细胞干细胞治疗可以减轻COPD患者的外周淋巴细胞亡.
- MSCs对淋巴细胞活力的治疗效果在COPD表型之间有所不同.
- 需要进一步的研究来阐明机制,并开发针对COPD的类型特异性MSC治疗方法.
更多相关视频
03:50Acupoint Application Combined with Acupoint Massage for Treating Constipation in a Patient with Chronic Obstructive Pulmonary Disease
Published on: August 18, 2023
1.8K
08:17Generation of a Chronic Obstructive Pulmonary Disease Model in Mice by Repeated Ozone Exposure
Published on: August 25, 2017
10.9K
相关概念视频
01:26COPD: Management Using Bronchodilators and Corticosteroids
194
Chronic obstructive pulmonary isease (COPD) involves a group of progressive lung disorders characterized by persistent airflow limitation and chronic respiratory symptoms. Asthma-COPD Overlap Syndrome (ACOS), encompassing features of both asthma and Chronic obstructive pulmonary disease (COPD), is a group of progressive lung disorders that includes chronic bronchitis, emphysema, and refractory (non-reversible) asthma. ACOS leads to complex clinical presentations that combine the inflammatory...
194
01:20COPD: Pathogenesis and Clinical Features
257
Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
257
01:01Regulation of Hematopoietic Stem Cells
3.2K
All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
3.2K
01:21Stem Cell Therapy for Tissue Regeneration
4.0K
Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
4.0K
01:20Chronic Obstructive Pulmonary Disease-II: Pathophysiology
2.8K
Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
Chronic Inflammation
2.8K
01:29Chronic Obstructive Pulmonary Disease-V: Management
2.5K
Managing Chronic Obstructive Pulmonary Disease (COPD) involves a multifaceted approach to reduce symptoms, prevent exacerbations, improve overall health status, and slow disease progression. Key strategies include lifestyle modifications, pharmacotherapy, supportive therapies, and, in some cases, surgery. Here is an overview of the primary COPD management strategies:
Smoking Cessation
Smoking Cessation
2.5K