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间歇性和温和的冷刺激通过对NF-κB和MAPK信号通路上的CIRP和TRPM8的共同调节来增强 brojlers的免疫功能

Lu Xing¹, Haochen Li¹, Deyang Miao¹

¹College of Life Science, Northeast Agricultural University, Harbin, 150030, China.

Poultry science

|July 10, 2024

概括

间歇性和轻度寒冷刺激 (IMCS) 通过调节寒冷冲击蛋白R (CIRP) 和短暂受体潜力 melastatin 8 (TRPM8) 途径来增强 brojler 免疫功能. 这可以改善寒冷的适应性,而不会损害心脏组织.

科学领域:

动物科学动物科学
免疫学免疫学免疫学
身体生理学身体生理学

背景情况:

适应寒冷对于肉的健康和生产率至关重要.
免疫功能是家禽成功适应寒冷的关键指标.
了解冷适应背后的分子机制对于优化肉福利至关重要.

研究的目的:

为了研究间歇性和轻度冷刺激 (IMCS) 对 brojler 免疫功能的影响.
为了阐明涉及CIRP,TRPM8,NF-κB和MAPK通路的分子机制,冷压肉.
评估IMCS对 brojiler心脏健康的影响.

主要方法:

192只一天大的罗斯308肉被分为控制组和冷刺激组.
寒冷刺激包括从15日到35日每天减少3°C,每天5小时.
在心脏组织和血清中分析了关键免疫标记物 (CIRP,TRPM8,NF-κB,MAPK通路组件) 和细胞因子的基因和蛋白质表达水平.

主要成果:

IMCS并没有导致心肌损伤.
在第22天,IMCS显著提高了心脏和血清中的免疫标记物和细胞因子的调节.
在第36天和第43天,IMCS对基因和蛋白质表达产生了多种影响,表明复杂的免疫调节,最终增强了免疫功能.

结论:

IMCS有效地增强肉的免疫功能.
在NF-κB和MAPK通路上的CIRP和TRPM8的共同调节介导了这种免疫增强.
IMCS有助于改善肉的寒冷适应,没有对心脏产生不良影响.

关键词:

在CIRP中,CIRP是指CIRP.在TRPM8中,我们可以使用TRPM8.牛肉的心脏牛肉的心脏寒冷刺激是一种刺激.免疫力是一种免疫力.

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