在精神分裂症中,口腔微生物组与大脑静止状态连接之间的关联
Dongdong Lin1, Zening Fu1, Jingyu Liu1
1Tri-institutional Center for Translational Research in Neuroimaging and Data Science (TReNDS), Georgia State, Georgia, Tech, Emory, Atlanta, GA 30303, United States of America.
Schizophrenia research
|July 10, 2024
概括
精神分裂症 (SZ) 与口腔微生物组的变化和大脑连接的改变有关. 这项研究发现了不同的微生物组成及其与SZ患者大脑网络功能障碍的相关性.
科学领域:
- 神经科学是一个神经科学.
- 微生物学 微生物学
- 精神病学是一个精神病学.
背景情况:
- 微生物组-大脑轴影响大脑功能和精神疾病.
- 环境因素,包括口腔微生物群,可能在精神分裂症 (SZ) 中起作用.
研究的目的:
- 调查口腔微生物组组成和精神分裂症中大脑功能连接之间的联系.
- 确定与SZ相关的特定微生物变化及其与大脑网络功能障碍的相关性.
主要方法:
- 16S rRNA基因测序用于分析213名SZ患者和健康对照组的口腔微生物组.
- 休息状态功能磁共振成像 (rsfMRI) 对139名受试者进行,以评估大脑功能连接.
- 采用多变量统计分析,将微生物组数据与神经成像发现相关联.
主要成果:
- 在SZ患者和对照人群之间观察到口腔微生物组合 (β多样性) 的显著差异.
- 在炎症,神经递质信号传递和H2S生产中发挥作用的14种微生物物种显示SZ的丰度发生变化.
- 在特定的微生物和大脑功能连接组件之间发现了显著的相关性,SZ的分类准确度很高 (AUC = 0.84-0.87).
结论:
- 口腔微生物组失调可能与精神分裂症中大脑功能连接的改变有关.
- 免疫学,神经递质信号传递和HPA轴路径可能会调解这些效应.
- 需要进一步的研究来阐明口腔微生物组在SZ病理生理学中的作用.
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