尿路稀土元素与功能之间的关联:来自中国广西的横截面研究的发现
Xingxi Luo1, Suyang Xiao1, Dongping Huang2
1Department of Epidemiology and Health Statistics, School of Public Health, Guangxi Medical University, Nanning, Guangxi 530021, China.
概括
对稀土元素 (REEs) 的暴露与中国成年人功能标志物增加有关. (Pr), (La) 和新 (Nd) 显示出显著的关联,表明潜在的环境暴露值.
科学领域:
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
- 流行病学 流行病学
背景情况:
- 稀土元素 (REE) 具有广泛的工业应用,引发了公众健康的担忧.
- 在体内研究表明,REEs会影响功能,但流行病学数据有限.
- 这项研究调查了REEs暴露和功能之间的流行病学联系.
研究的目的:
- 检查暴露于12种不同稀土元素 (REEs) 对人类人群功能的影响.
- 为了确定与估计膜过率 (eGFR) 的变化相关的特定REEs.
- 通过使用先进的统计模型,探索REE联合暴露对功能的综合影响.
主要方法:
- 一项涉及中国广西1052名参与者的横截面研究.
- 尿中的REE度使用诱导合血质谱法 (ICP-MS) 测量.
- 多重线性回归,加权量子总和 (WQS) 回归和贝叶斯内核机器回归 (BKMR) 模型用于分析REE-eGFR关系.
主要成果:
- 尿液中度增加的 (La), (Ce), (Pr), (Nd) 和 (Dy) 与升高的EGFR显著相关.
- WQS和BKMR模型证实了混合REE暴露与eGFR之间的关联,Pr显示了最强的相关性.
- 观察Pr和La,Pr和Nd之间的相互作用,表明对功能有协同作用.
结论:
- 同时暴露于REEs与升高的eGFR有关,这表明对功能可能有影响.
- (Pr) 似乎是影响eGFR增加的关键元素,可能因同时暴露于 (La) 和 (Nd) 而加剧.
- 混合,低剂量的REE暴露可能对功能产生保护作用,这表明环境暴露值.
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