急性疹:症状,原因和表现型的评估容易慢性化
Begum Gorgulu Akin1, Sengul Beyaz2, Zeynep Celebi Sozener2,3
1Immunology and Allergy, Ankara Bilkent City Hospital, Ankara, Turkey, drbegumgorgulu@gmail.com.
International archives of allergy and immunology
|July 10, 2024
概括
急性疹 (AU) 通常很快消失,但观察到24.7%的慢性病率. 在AU患者中测试抗甲状腺过氧化酶 (anti-TPO) 可能有助于预测患慢性疹 (CU) 的风险.
科学领域:
- 皮肤病学 皮肤病学
- 免疫学 免疫学 免疫学
- 过敏 过敏是一种过敏.
背景情况:
- 疹,以疹和/或血管为特征,被分为急性 (<6周) 或慢性 (>6周).
- 疾病活动通常使用患者报告的结果指标进行评估,例如疹活动评分 (UAS-7) 和疹控制测试 (UCT).
- 了解导致疹慢性发展的因素对于有效管理至关重要.
研究的目的:
- 调查慢性和已康复的疹患者在人口统计,症状和疾病严重程度方面的差异.
- 确定最初呈现急性疹症 (AU) 的患者慢性病的潜在预测因素.
- 在6个月的随访期内评估疾病的进展和对AU的控制.
主要方法:
- 一组109名疹患者被跟踪了6个月.
- 基线和后续评估包括例行测试,抗甲状腺过氧化酶 (抗TPO) 抗体水平,视觉模拟量表 (VAS),UCT,UAS-7和药物评分 (MSs).
- 患者在初始检查后的1,3个月和6个月被评估.
主要成果:
- 该研究发现,AU患者的慢性发病率为24.7%.
- 阳性抗甲状腺过氧化酶 (抗TPO) 抗体与患慢性疹 (CU) 的风险增加1.69倍有关.
- 从基线到6个月的CU患者中,在VAS,UCT,UAS-7和MSs中发现了显著的改善.
结论:
- 急性疹通常没有进展到慢性,但显著的百分比可以成为慢性.
- 在患有AU的患者中,查抗甲状腺过氧化酶 (抗TPO) 可能对预测疾病进程和慢性风险有益.
- 对疹慢性病的具体原因进行进一步研究是有必要的.
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