动脉置换患者贫血的预后影响:一项全国性的研究
Daniel Alexander Brems1, Jeppe Kofoed Petersen1, Xenia Begun1
1Department of Cardiology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
概括
大动脉置换后中度至严重的贫血与更高的死亡风险,再入院和心房动在一年内相关. 轻度贫血不显示这些增加的风险.
科学领域:
- 心脏病学 心脏病学
- 血液学 血液学 血液学
- 公共卫生 公共卫生
背景情况:
- 大动脉置换 (AVR) 与高患者再入院率有关.
- 贫血是一种潜在的可修改风险因素,影响AVR后的结果.
- 这项研究调查了出院时贫血和随后的患者健康事件之间的联系.
研究的目的:
- 确定出院时贫血严重程度与AVR后一年的不良结果之间的关联.
- 确定贫血是否是死亡,住院,心力衰竭和AVR后心房动的重要预测因素.
主要方法:
- 利用丹麦全国性的登记册来识别在2015-2021年期间接受AVR的患者.
- 将患者分为中度/重度贫血 (血红蛋白<6.2 mmol/L) 和无/轻度贫血 (血红蛋白≥6.2 mmol) 的组.
- 采用多变量考克斯回归来比较一年的结果,包括全因死亡率,全因住院,心力衰竭住院和心房动住院.
主要成果:
- 鉴定了8614名患者;33.1%患有中度/重度贫血.
- 中度/重度贫血与全因死亡率 (HR 1.27),全因入院率 (HR 1.22) 和心房入院率 (HR 1.23) 的一年高得多.
- 在中度/重度贫血和心力衰竭入院之间没有发现显著的关联 (HR 1.09).
结论:
- 在AVR后出院时,中度至严重的贫血是增加全因死亡率和一年内入院的重要危险因素.
- AVR后的贫血也与心房的发病率较高有关.
- 在这个队列中,心力衰竭入院与出院时的贫血严重程度没有显著相关.
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