肉症和结直肠癌没有远程转移的生存率:系统性审查和元分析
Wen-Li Lin1,2, Thi-Hoang-Yen Nguyen3, Wen-Tsung Huang4
1Center for Quality Management, Chi Mei Medical Center, Tainan City, Taiwan.
Journal of gastroenterology and hepatology
|July 10, 2024
概括
肌肉质量的损失 - - 萨尔科佩尼亚 - - 与没有远程转移的结直肠癌患者的存活率较差有关. 这包括整体生存率和无疾病生存率,无论何时确定了肉症.
科学领域:
- 在瘤学瘤学.
- 老年病的医生 老年病的医生
- 手术瘤学手术瘤学
背景情况:
- 萨科佩尼亚,或肌肉质量损失,是癌症护理中日益关注的问题.
- 之前关于萨科佩尼亚对结直肠癌 (CRC) 存活率的影响的研究已经产生了不一致的结果.
- 需要全面评估CRC患者的萨尔科佩尼亚预后价值.
研究的目的:
- 进行一项元分析,评估在非转移性结直肠癌 (CRC) 患者中肉类和生存率之间的关联.
- 汇总来自多项研究的数据,以提供更可靠的估计萨科佩尼亚的影响.
- 为了澄清CRC中肉症的预后意义.
主要方法:
- 在主要数据库中进行了系统的文献搜索.
- 包括的研究使用纽卡斯尔-太华尺度评估了质量.
- 进行了元分析,以确定萨科佩尼亚对整体生存期 (OS) 和无病生存期 (DFS) 的影响.
主要成果:
- 分析了13项涉及6600名参与者的研究.
- 手术前的sarcopenia显着与更糟糕的OS (HR: 1.61) 和DFS (HR: 1.57) 有关.
- 手术后的sarcopenia也与更糟糕的OS (HR: 1.76) 和DFS (HR: 1.79) 相关联.
结论:
- 麻症是非转移性结直肠癌患者生存率降低的重要预测因素.
- 萨科佩尼亚对生存的负面影响是显而易见的,无论是在瘤切除之前还是之后检测到的.
- 这些发现强调了在CRC的管理和预后中考虑肉症的重要性.
相关概念视频
01:21Cancer Survival Analysis
340
Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
340
02:07Tumor Progression
6.3K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
6.3K