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化学抗原受体诱导的抗原损失可以保护CD5.CART细胞免受兄弟杀伤,而不会影响目标细胞毒性

Royce Ma1, Mae Woods2, Phillip Burkhardt3

  • 1Center for Cell and Gene Therapy, Baylor College of Medicine, Texas Children's Hospital, Houston, TX 77030, USA; Graduate Program in Immunology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA; William T. Shearer Center for Human Immunobiology, Texas Children's Hospital, Houston, TX 77030, USA; Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA.

Cell reports. Medicine
|July 10, 2024
PubMed
概括

针对CD5的化学抗原受体T (CART) 细胞通过降低抗原的调节来防止自我损伤. 这一策略使得有效的T细胞癌症治疗,同时节省健康的T细胞.

关键词:
汽车 汽车 汽车 汽车CD5 CD5 CD5 CD5 CD5 CD5 CD5 CD5 CD5 CD5 CD5 CD5 CD5 CD5 CD5 CD5 CD5 CD5 CD5在T细胞兄弟杀戮中.在T细胞恶性瘤中.仿制性抗原受体的复制性受体.临床试验是指临床试验中的临床试验.杀害兄弟的方法是兄弟杀戮.瘤外毒性 有毒性

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