针对大动脉吐的专用制造与非标签型跨导管器件的性能:PURPOSE研究
Enrico Poletti1, Matti Adam2, Hendrik Wienemann2
1IRCCS Policlinico San Donato, San Donato Milanese, Milan, Italy.
JACC. Cardiovascular interventions
|July 10, 2024
概括
耶纳门三部曲 (JVT) 显示出优越的急性性能,与其他跨导管心脏门 (THVs) 相比,用于非标签的严重大动脉吐在不可手术的患者. 需要进行更长的随访,以确认长期预后影响.
科学领域:
- 心脏病学 心脏病学
- 干预心脏病学 干预心脏病学
- 医疗器械 医疗器械
背景情况:
- 严重的纯大动脉吐 (AR) 具有显著的死亡率和发病率风险,由于手术风险,往往治疗不足.
- 通过导管的心脏门 (THVs) 在严重的AR治疗中使用非标签,产生了低于最佳的结果.
- 专门构建的Jena Valve Trilogy (JVT) 已经显示出希望,但缺乏比较数据.
研究的目的:
- 为了比较最新的超导管心脏门 (THVs) 的性能,使用非标签与专门建造的Jena Valve Trilogy (JVT) 相比.
- 为了评估严重主动脉反的不可手术患者的结果.
主要方法:
- 一个多中心的回顾性注册表,涉及18个国际中心.
- 包括患有严重本源膜AR的不可手术的患者,不包括双主动脉.
- 主要终点包括技术和设备的成功,1年全因死亡率和死亡率和心力衰竭再住院的复合.
主要成果:
- 与非标签THV相比,Jena Valve Trilogy (JVT) 的技术 (98%对81%) 和设备成功率 (95%对73%) 较高.
- 联合静脉治疗显示THV栓塞率显著降低 (1.1%对15%),需要第二个门 (1.1%对11%) 和中度残留AR (1.1%对10%).
- 一年全因死亡率和复合终点在JVT和非标签THV组之间没有显著差异.
结论:
- 耶纳三部曲 (JVT) 平台表现出优越的急性性能比其他跨导管心脏 (THVs) 当在不可手术的严重大动脉吐患者的非标签使用时.
- 需要进一步的长期随访,以确定对患者预后的任何潜在影响.
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