药物堕胎与同时启动孕激素避孕药的有效性:一个回顾性队列研究
Anna L Carroll1, Anna M Strauss2, Nicole M Philipps2
1Department of Obstetrics, Gynecology & Women's Health, University of Minnesota, Minneapolis, MN, United States.
Contraception
|July 10, 2024
概括
与药物流产 (MAB) 同时注射储存的美德酸 (DMPA) 可能会降低MAB的疗效. 然而,与MAB同时安装etonogestrel植入物似乎不会影响结果,为避孕咨询提供信息.
科学领域:
- 生殖健康 生殖健康
- 药理学 药理学是指药理学的学科.
- 避孕药是一种避孕药,用于避孕.
背景情况:
- 药物流产 (MAB) 是一种广泛使用的妊娠终止方法.
- 与MAB同时做出的避孕选择可能会影响其有效性.
- 了解这些相互作用对于有效的生殖健康保健至关重要.
研究的目的:
- 评估并发避孕对MAB结果的影响.
- 为了比较MAB在接受储存麦德洛西孕酸盐 (DMPA) 注射或以格斯特勒植入剂的患者与没有接受MAB的患者的疗效.
- 以实践数据为基础,为堕胎后的避孕咨询提供信息.
主要方法:
- 2017-2019年MAB患者的回顾性队列研究.
- 抽象了电子健康记录,以比较不同组的结果.
- 后勤回归被用来分析治疗失败率,调整关键变量.
主要成果:
- 在7296名MAB参与者中,3.1%同时接受DMPA和4.2%同时接受乙凝植入物.
- 在DMPA组中,对MAB失败进行额外治疗的比例更高 (比较组的9.9%与2.1%相比;aOR 4.26).
- 与对照组相比,乙格斯特勒植入组在MAB失败率上没有显著差异 (3.0%对2.1%;aOR 1.38).
结论:
- 与mifepristone同时使用DMPA可能会降低MAB的疗效.
- 与米费普里斯顿同时安装etonogestrel植入物似乎不会改变MAB的结果.
- 这些发现支持现有的文献,并指导MAB后的避孕咨询.
相关概念视频
Birth Control Methods
226
Vasectomy is a surgical form of male sterilization that involves severing and sealing the vasa deferentia, preventing sperm from mixing with semen during ejaculation. Because a vasectomy does not impact the testes' ability to produce testosterone, hormone levels, libido, and sexual function generally remain unchanged. While vasectomy is highly effective in preventing pregnancy, with a success rate near 99.85%, rare cases of recanalization (spontaneous reconnection) can occur. Although...
226
Drugs for Treatment of Constipation-Predominant IBS
154
Pharmacological therapies for IBS-C are designed to alleviate abdominal discomfort and enhance bowel function. In patients with IBS-C, fiber supplements may help soften stools and decrease straining, but may also lead to increased gas production and bloating. Osmotic laxatives like milk of magnesia are frequently used to soften stools and increase stool frequency in IBS-C patients. In addition, two drugs approved for use in severe IBS-C adult cases are linaclotide (Linzess) and lubiprostone...
154
Drugs for Peptic Ulcer Disease: Prostaglandin Analogs as Mucosal Protective Agents
395
The gastric mucosa produces prostaglandins E2 (PGE2) and prostacyclin (PGI2), crucial in maintaining gastric health. They exert cytoprotective effects, including increasing bicarbonate secretion, releasing protective mucin, reducing gastric acid output, and preventing harmful vasoconstriction. These effects are mediated through various receptors, such as EP1, EP2, EP3, and EP4.
Non-steroidal anti-inflammatory drugs (NSAIDs) can induce peptic ulcers by inhibiting cyclooxygenase, decreasing...
Non-steroidal anti-inflammatory drugs (NSAIDs) can induce peptic ulcers by inhibiting cyclooxygenase, decreasing...
395
Ovarian Cycle
1.1K
The menstrual cycle includes a critical component known as the ovarian cycle, which undergoes two main phases each month—the follicular phase and the luteal phase. The follicular phase is variable and averaging around 14 days. Ovulation, triggered by a surge in luteinizing hormone (LH), marks the transition between the two phases. The second phase, the luteal phase, is relatively consistent, lasting approximately 14 days, and is marked by the activity of the corpus luteum. While a cycle...
1.1K
Dose-Response Relationship: Potency and Efficacy
4.3K
The potency of a drug is the measure of its ability to produce a biological response and can be compared by looking at the half-maximum effective concentration or EC50 values of different drugs. A lower EC50 value indicates higher potency of the drug. In the dose–response curve of two antihypertensive drugs, candesartan and irbesartan, a significant difference is observed in their EC50 values. A lower EC50 value for candesartan indicates that it is more potent than irbesartan, as it...
4.3K
Combined Effects of Drugs: Synergism
3.8K
Synergism is a useful mechanism where combining two or more drugs is more effective than each constituent used alone. Such combinations are also called supra-additive interactions. The drugs collectively enhance the final therapeutic effect by acting on different targets. Another advantage is that the low dose of each constituent drug is sufficient to achieve the desired effect. This helps reduce the duration of therapy and lower the adverse effects of these drugs.
Such synergistic combinations...
Such synergistic combinations...
3.8K


