在患有易怒肠综合征和重度抑郁症的患者中,前额状系统功能模式的共同和明显的偏差
Qiqing Sun1, Nana Xiong1, Yuwei Wang2
1Peking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Beijing, China.
Journal of affective disorders
|July 10, 2024
概括
刺激性肠综合征 (IBS) 和主要抑郁症 (MDD) 在前-状回路中共享改变的大脑连接. 这些发现可能会解释它们的并发症和独特的症状.
科学领域:
- 神经科学是一个神经科学.
- 胃肠病学 胃肠病学
- 精神病学是一个精神病学.
背景情况:
- 刺激性肠综合征 (IBS) 和严重抑郁症 (MDD) 之间存在很高的并发症.
- 共同的风险因素和遗传途径表明存在重叠的生物机制.
- 假设IBS和MDD之间大脑功能的共同和疾病特异性变化.
研究的目的:
- 调查IBS和MDD患者之间大脑功能的共同和疾病特异性变化.
- 探索IBS中大脑功能和临床变量之间的关系.
- 为了确定IBS和MDD的潜在跨诊断标志物.
主要方法:
- 休息状态功能性MRI (fMRI) 在39名IBS患者,39名MDD患者和40名健康对照 (HC) 上进行.
- 功能连接性 (FC) 通过使用12个纹状体子区域作为种子来评估.
- 记录了包括焦虑,抑郁,胃肠道症状和alexithymia在内的临床变量.
主要成果:
- 与HC患者相比,IBS和MDD患者都显示出异常的额头状回路.
- 在两组中,在背条纹体和海马体,感觉运动皮质和前额皮质 (PFC) 之间观察到常见的降低FC.
- 在IBS患者中,表现出肌内FC和腹部肌-感觉运动皮层连接性下降.
- 患有MDD的患者表现出中枢PFC-边缘系统连接性增加.
- 额头-状肌的FC值显示出作为IBS和MDD的跨诊断标记物的潜力.
- 在IBS患者中,条纹连接与腹痛,焦虑和alexithymia负相关.
结论:
- IBS和MDD共享共同的前额-状回路损伤.
- 前额状回路的疾病特异性变化有助于形成不同的表型.
- 这些发现为IBS-MDD并发症的神经生物学基础提供了洞察力.
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