在研究队列代表性测量中利用地理空间分布
Keith Feldman1, Natalie J Kane2, Stacey Daniels-Young3
1Health Services and Outcomes Research, Children's Mercy Kansas City, 2401 Gillham Road, Kansas City, MO 64108, USA; Department of Pediatrics, University of Missouri-Kansas City School of Medicine, 2411 Holmes Street, Kansas City, MO 64108, USA.
Journal of biomedical informatics
|July 10, 2024
概括
新的指标通过结合地理数据来评估研究队列的代表性. 这有助于确保研究结果可以对预期的人群进行概括,改善翻译科学成果.
科学领域:
- 翻译科学 翻译科学
- 健康 公平 卫生 公平
- 生物统计学 生物统计学
背景情况:
- 研究结果对更广泛的人群的概括性对于翻译科学至关重要.
- 目前评估队列代表性的方法往往忽视了地理和社会人口因素.
- 地理位置显著影响健康结果,可以揭示子组错位.
研究的目的:
- 引入新的指标来量化研究队列代表性.
- 将地理信息纳入评估队列与目标人群的一致性.
- 解决现有方法的局限性,即将队列视为单一的实体.
主要方法:
- 定义了两个主题的指标:招聘模式和个人特征.
- 对参考人口的评估招聘率和地理分布.
- 评估了社会人口,临床和地理多样性,并考虑了地理空间的接近性.
主要成果:
- 经验证明的方法使用了对黑人/非裔美国患者喘的临床研究.
- 在个人层面上确定过度和不足招聘的领域.
- 突出了确定队列与人口相似的特定特征和错位区域的能力.
结论:
- 为研究队伍开发了一个全面的空间评估框架.
- 为研究人员提供了评估和定位研究结果概括性的工具.
- 强调了地理背景在实现代表性研究设计中的重要性.
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