在脑血管随机对照试验中报告参与者的种族和种族
Joanna M Roy1, Alexander J Schupper2, Shahram Majidi2
1Topiwala National Medical College, Mumbai, India.
World neurosurgery
|July 10, 2024
概括
大多数脑血管随机对照试验 (RCT) 不报告参与者的种族和种族,阻碍了对结果差异的理解. 北美研究和更高的期刊影响因素与报告增加有关.
科学领域:
- 神经学 神经学
- 临床试验 临床试验
- 健康差异 在健康上的差异
背景情况:
- 随机对照试验 (RCT) 对脑血管疾病管理至关重要.
- 越来越多的证据表明,种族和种族独立地预测患者的结果.
- 在RCT中对人口概况的报告不足令人担忧.
研究的目的:
- 描述大脑血管RCT中种族和/或种族的报告趋势.
- 确定影响这些试验中种族和/或种族报告的因素.
主要方法:
- 在科学网络中系统地搜索引述最多的脑血管RCT.
- 包括相关的美国心脏协会指南.
- 单变量和多变量分析以评估报告因素.
主要成果:
- 65%的脑血管RCT未能报告参与者的种族/种族.
- 来自北美的研究显示,报告的几率显着更高 (14.74倍).
- 较高的期刊影响因子与报告概率增加 (1.007倍) 相关联.
- 种族/种族报告没有因时间,研究规模,资金或中心而有所不同.
- 在报告时,与白人相比,黑人和亚洲人群的代表性不足.
结论:
- 大多数知名的脑血管RCT缺乏足够的种族/种族报告.
- 这种报告不足的原因需要进一步调查.
- 解决报告缺口对于理解和减轻脑血管疾病的健康差异至关重要.
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