使用3D快速低角度拍摄定位器的渐进性超核麻的基于voxel的形态学图像:与磁化准备的快速梯度回声图像进行比较
Cong Shang1,2, Shohei Inui3, Daita Kaneda4
1Department of Radiology, National Center for Geriatrics and Gerontology, Obu, Aichi, Japan.
概括
这项研究发现,MPRAGE和L3DFLASH序列在渐进性上核性麻 (PSP) 中对白质 (WM) 缩的基于声素的形态学 (VBM) 分析中都是有效的. 序列显示了类似的WM缩模式,证实了它们在PSP研究中的实用性.
科学领域:
- 神经成像是一种神经成像.
- 神经学 神经学
- 医学成像分析 医学成像分析
背景情况:
- 基于素的形态测量 (VBM) 是研究渐进性超核性麻 (PSP) 中白质缩的一个关键技术.
- 高分辨率的3D T1加权成像,如MPRAGE,是常用的,但PSP中VBM的其他3D序列的有效性仍未得到充分探索.
研究的目的:
- 评估使用3D快速低角度拍摄 (L3DFLASH) 序列用于PSP患者WM缩的VBM分析的可行性.
- 将L3DFLASH识别的WM缩模式与MPRAGE序列中的WM缩模式进行比较.
主要方法:
- 追溯分析12名PSP患者和18名健康对照人群,所有人均使用L3DFLASH和MPRAGE序列进行扫描.
- 使用统计参数映射 (SPM) 和计算解剖学工具箱 (CAT12) 进行VBM分析.
- 使用线性回归和布兰德-阿尔特曼图表评估序列之间的WM体积协议.
主要成果:
- 使用L3DFLASH和MPRAGE进行的VBM分析揭示了PSP中类似的WM缩模式,特别是在中脑,pons,thalamus和前中心.
- L3DFLASH独特地确定了前骨和右上顶叶中的灰质缩.
- 虽然WM体积测量略有差异,但Bland-Altman图表显示WM体积序列之间的一致性超过90%.
结论:
- 两种MPRAGE和L3DFLASH序列都适用于PSP中WM缩的VBM分析.
- L3DFLASH为PSP中的VBM研究提供了一个可行的替代方案,可能揭示灰色质缩的独特模式.
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