脑下垂体激素缺乏导致地松鼠在冬眠期间出现生理性厌食症
Sarah M Mohr1,2,3, Rafael Dai Pra1,2,3, Maryann P Platt1,2,3
1Department of Cellular and Molecular Physiology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT, 06510, USA.
Nature communications
|July 10, 2024
概括
哺乳动物冬眠者,如地松鼠,由于可逆的食中心抑制,在兴奋期间不会感到饥饿. 甲状腺激素缺乏导致这种冬眠厌食症.
科学领域:
- 生理学 生理学 生理学
- 神经内分泌学神经内分泌学
- 比较生物学的比较生物学
背景情况:
- 哺乳动物冬眠者通过调节生理学来适应寒冷和食物短缺.
- 冬眠涉及和交叉激发 (IBA) 状态.
- 冬眠适应的机制,特别是养调节,尚未完全理解.
研究的目的:
- 为了研究冬眠地松鼠在交叉激发期间抑制食行为的机制.
- 确定下丘脑养中心和冬眠厌食症中的关键激素的作用.
主要方法:
- 在整个冬眠季研究了十三条线的地松鼠 (Ictidomys tridecemlineatus).
- 在间隔激发 (IBA) 期间监测食行为和饥饿感.
- 评估了下丘脑弧形核神经元对 ghrelin 和 leptin 的敏感性.
- 在IBA期间给予下丘脑甲状腺激素输液,以观察养的影响.
主要成果:
- 尽管禁食,地松鼠在IBA期间表现出微不足道的饥饿感.
- 在IBA期间,下丘脑弧形核神经元对 ghrelin 和 leptin 的敏感性降低.
- 在IBA期间给予甲状腺激素成功恢复了食行为 (救助冬眠厌食症).
结论:
- 甲状腺激素缺乏是导致地松鼠冬眠厌食症的关键因素.
- 下丘脑的养中心在冬眠期间表现出功能灵活性.
- 这些发现揭示了生存在长期资源稀缺时期的关键适应性.
相关概念视频
Regulation of Food Intake
216
Short-term regulation of food intake primarily involves neural signals from the gastrointestinal (GI) tract, blood nutrient levels, and GI tract hormones. Communication between the gut and brain via vagal nerve fibers plays a significant role in evaluating the contents of the gut. Clinical studies have shown that protein ingestion produces a more prolonged response in these nerve fibers compared to an equivalent amount of glucose. Additionally, the activation of stretch receptors caused by GI...
216
Major Hormones and Their Functions
366
Hormones, the biochemical messengers produced by endocrine glands, are pivotal in regulating bodily functions and maintaining homeostasis. Each hormone's balance is crucial; imbalances can lead to significant physiological disruptions. Major hormones include oxytocin, cortisol, epinephrine, estrogen, testosterone, thyroxine, growth hormone, insulin, and glucagon.
Oxytocin, produced in the hypothalamus and released by the pituitary gland, plays a role in social bonding, childbirth, and...
Oxytocin, produced in the hypothalamus and released by the pituitary gland, plays a role in social bonding, childbirth, and...
366
Hypoglycemia and Glucagon
254
Without prolonged fasting, healthy individuals maintain blood glucose levels above 3.5 mM due to a well-adapted neuroendocrine counterregulatory system that effectively prevents acute hypoglycemia, a potentially life-threatening condition. The primary clinical scenarios for hypoglycemia encompass diabetes treatment, inappropriate production of endogenous insulin or insulin-like substances by tumors, and the use of glucose-lowering agents in non-diabetic individuals. Notably, hypoglycemia in the...
254
Anorexia Nervosa
58
Anorexia nervosa is a complex and severe eating disorder characterized by an intense fear of weight gain, an unrelenting pursuit of thinness, and a distorted body image. It often leads to dangerously low body weight relative to an individual's age and height. This disorder is marked by significant physical and psychological consequences, making it one of the most life-threatening psychiatric illnesses.
Symptoms and Physical Effects
Individuals with anorexia nervosa commonly exhibit extreme...
Symptoms and Physical Effects
Individuals with anorexia nervosa commonly exhibit extreme...
58
Primary Motives: Hunger and Thirst
174
Hunger and thirst are fundamental physiological drives crucial for maintaining homeostasis and ensuring the survival of both humans and animals. These drives are regulated through complex interactions between the brain, hormones, and sensory receptors.
Hunger arises when the brain detects changes in the body's nutrient levels, including glucose, lipids, amino acids, and hormones such as ghrelin and leptin. The hypothalamus plays a central role in hunger regulation. The lateral hypothalamus...
Hunger arises when the brain detects changes in the body's nutrient levels, including glucose, lipids, amino acids, and hormones such as ghrelin and leptin. The hypothalamus plays a central role in hunger regulation. The lateral hypothalamus...
174
Regulation of Hormone Secretion
3.4K
Regulation of hormone secretion is a finely tuned orchestration driven by various types of stimuli, encompassing neural, humoral, and hormonal signals. Environmental cues instigate neural stimuli, where action potentials traverse nerve fibers to reach their designated targets. An illustrative scenario is the body's response to stress, wherein the sympathetic nervous system releases epinephrine from the adrenal glands, inducing the well-known 'fight or flight' reaction.
Humoral...
Humoral...
3.4K


