在2型糖尿病中尿液生物标志物,有或没有微血管并发症
Chanyuan Zhang1, Tiebing Liu2, Xiaoqian Wang1
1Department of Clinical Laboratory, Civil Aviation General Hospital (Peking University Civil Aviation School of Clinical Medicine), Beijing, China.
Nutrition & diabetes
|July 10, 2024
概括
N-乙-β-D-葡萄糖胺酶 (u-NAG) 是一种关键的尿液生物标志物,用于早期检测2型糖尿病 (T2DM) 中的损伤. 建议对新诊断的T2DM患者进行u-NAG测量,以监测脏健康.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 内分泌学 在内分泌学.
- 生物标志物发现发现
背景情况:
- 2型糖尿病 (T2DM) 是慢性病的主要原因.
- 早期发现糖尿病病 (DKD) 对于有效管理和预防并发症至关重要.
- 微血管并发症,如糖尿病视网膜病变 (DR) 和白色素尿 (以尿中的白色素-肌素比率 (UACR) 表示) 是DKD进展的指标.
研究的目的:
- 调查9个尿液生物标志物在T2DM患者中的分布和意义.
- 评估这些生物标志物的实用性,以检测损伤,有或没有微血管并发症.
- 以健康个体为基础,为这些生物标志物设定参考限值.
主要方法:
- 招募了407名T2DM患者和112名健康对照.
- 根据DR和UACR状态将T2DM患者分为四组:DR(-) UACR(-),DR(+) UACR(-),DR(-) UACR(+),DR(+) UACR(+).
- 测量了九种尿液生物标志物:u-α1MG,u-IgG,u-NGAL,u-CysC,u-RBP,u-β2MG,u-NAG,u-Trf和u-Col,使用健康对照的97.5百分点水平作为上限参考值.
主要成果:
- 在健康个体和T2DM患者之间,N-乙-β-D-葡萄糖胺酶 (u-NAG) /肌素 (Cr) 水平有显著差异.
- 在DR-) UACR-) 组中,转激素 (u-Trf) /Cr的阳性率最高 (21.37%),其次是免疫球蛋白G (u-IgG) /Cr (14.52%) 和u-NAG/Cr (10.48%).
- 大约17.34%的T2DM患者对两个或两个以上的生物标志物呈阳性;对于一个或两个生物标志物的阳性率在T2DM持续时间小于五年的患者中与DR-UACR-组相比相似.
结论:
- 尿液生物标志物,特别是与管相关的生物标志物,显示出糖尿病中损伤的早期检测和监测的潜力.
- N-乙-β-D-葡萄糖胺酶 (u-NAG) 是新诊断T2DM患者的推生物标志物,用于评估状况.
- 进一步的研究可以阐明这些生物标志物的特定作用在糖尿病病的不同阶段.
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