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炎症标志物和脆弱性进展的纵向分析:基于英国老化纵向研究

Lingxiao He¹, Jinzhu Yang¹, Ya Fang²

¹Center for Aging and Health Research, School of Public Health, Xiamen University, Xiang'an South Road, Xiamen, 361102, China.

European geriatric medicine

|July 10, 2024

概括

像hsCRP和WBC这样的炎症标志物与老年人的脆弱性进展有关. 这些标志物的较高基线水平预测了随着时间的推移发展脆弱的风险增加.

科学领域:

老年学是一门学科.
炎症研究炎症研究
生物标志物生物标志物

背景情况:

脆弱性是老龄化人口的重大健康问题,与健康状况不佳有关.
虽然炎症生物标志物和脆弱性之间存在截面联系,但纵向关联需要进一步调查.

研究的目的:

检查常见的炎症标志物和脆弱性进展之间的纵向关联.
调查过敏C反应蛋白 (hsCRP),白细胞 (WBC) 计数和纤维素素与随着时间的推移发展的脆弱性.

主要方法:

利用了2316名参与英国长度老化研究 (8年随访) 的数据.
从52个项目计算了脆弱指数 (FI).
采用混合效应模型和考克斯比例危险模型,控制年龄,性别和财富.

主要成果:

在截面上,更高的hsCRP,WBC和纤维素原水平与更高的FI相关.
从长度来看,基线hsCRP和WBC水平升高与脆弱性发展的风险增加有关.
没有观察到纤维素原与脆弱性进展相关的显著时间相互作用.

结论:

hsCRP,WBC和纤维素素作为一个时间点的脆弱状态的指标.
在8年的时间里,hsCRP和WBC是脆弱性进展的显著预测因素.
这些发现突显了特定炎症标志物在脆弱的纵向发展中的作用.

关键词:

年龄化衰老衰老生物标志物生物标志物脆弱性脆弱性脆弱性炎症炎症是一种炎症.

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