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新精神活性物质在原始废水中的稳定性

Bethan Davies¹, Richard Paul², David Osselton³

¹Bournemouth University, Christchurch House, Talbot Campus, Fern Barrow, Poole, BH12 5BB, UK. bdavies@bournemouth.ac.uk.

Forensic science, medicine, and pathology

|July 10, 2024

概括

新型精神活性物质 (NPS) 在废水中的稳定性因化学品类和储存条件而异. 在废水分析中检测代谢物更有利,因为它们的稳定性比原始药物更强.

科学领域:

环境化学环境化学
法医毒理学法医毒理学
分析化学分析化学

背景情况:

新兴的精神活性物质 (NPS) 由于其动态性质,对药物测试构成挑战.
在废水中检测NPS需要了解代谢物和降解产品的形成.
废水分析对于监测社区毒品使用趋势至关重要.

研究的目的:

研究在各种条件下在废水中选择的新型精神活性物质 (NPS) 的稳定性.
为了确定储存环境和时间对废水中NPS检测的影响.
为了比较原始NPS化合物的稳定性与其代谢物.

主要方法:

使用了液体染色学飞行时间质谱法 (LC-TOF-MS).
分析了七种NPS化合物及其内部标准.
废水样本经历了不同的储存条件:室温,冷藏,pH 2酸化和代硫酸盐处理.

主要成果:

废水中的NPS稳定性高度依赖于储存条件和时间.
合成大麻素显示出有限的稳定性,而类似于cathinone的物质更稳定.
与其母NPS化合物相比,代谢物在废水中表现出更大的稳定性.

结论:

最佳的储存和及时分析对于准确的NPS废水监测至关重要.
专注于代谢物分析可能会提高废水中NPS检测的可靠性.
了解NPS降解途径对于法医和公共卫生应用至关重要.

关键词:

在 LC-ToFMS 中.国家安全系统 (NPS) 是一个国家安全系统.在SPE中,SPE是SPE.稳定的稳定性稳定的稳定性废水是废水,废水就是废水.

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