在多发性骨髓瘤疫苗接种前和接种期间的免疫功能障碍:基于COVID-19的案例研究
Esperanza Martín-Sánchez1, Luis-Esteban Tamariz-Amador2, Camila Guerrero2
1Cancer Center Clinica Universidad de Navarra (CCUN), Centro de Investigacion Medica Aplicada (CIMA), Instituto de Investigacion Sanitaria de Navarra (IdiSNA), CIBER-ONC numbers CB16/12/00369 and CB16/12/00489, Pamplona, Spain. emartinsan@unav.es.
多发性骨髓瘤 (MM) 患者有免疫功能障碍,特别是B细胞和T细胞,影响疫苗的反应. B细胞计数可以预测免疫性,帮助MM患者个性化疫苗接种策略.
科学领域:
- 免疫学 免疫学 免疫学
- 血液学 血液学 血液学
- 在瘤学瘤学.
背景情况:
- 感染是多发性骨髓瘤 (MM) 死亡的主要原因.
- 在MM中潜在的免疫功能障碍的特定免疫细胞组成仍未确定.
- 了解这些细胞变化对于改善患者结果和疫苗疗效至关重要.
研究的目的:
- 确定与多发性骨髓瘤 (MM) 免疫功能障碍相关的免疫细胞概况.
- 用COVID-19作为案例研究来调查MM对疫苗反应的影响.
- 确定潜在的生物标志物来预测MM患者的疫苗免疫性.
主要方法:
- 周围血液免疫细胞的多维和计算流动细胞计分析.
- 在MM患者和健康对照中对COVID-19疫苗接种的免疫反应的分析.
- 对1099多个样本进行了纵向采样和数据分析.
主要成果:
- 在MM患者中,73%的免疫细胞类型,特别是B细胞和T细胞的分布发生了变化.
- 疫苗接种后MM患者表现出有限的B细胞扩张和较低的抗体标位.
- B细胞的百分比和数量,以及CD4+T细胞的百分比和树突细胞的数量,预测了疫苗的免疫性.
结论:
- 这项研究定义了MM中免疫功能障碍的细胞基础.
- B细胞百分比和绝对计数被确定为MM中疫苗反应的预测生物标志物.
- 这些发现支持基于免疫细胞概况的MM患者疫苗接种计划的个性化.
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