在六代新石器时代的农民中重复感染瘟疫
Frederik Valeur Seersholm1, Karl-Göran Sjögren2, Julia Koelman3
1Lundbeck Foundation GeoGenetics Centre, Globe Institute, University of Copenhagen, Copenhagen, Denmark. frederikseersholm@gmail.com.
Nature
|July 10, 2024
概括
古代基因组学揭示了斯堪的纳维亚新石器时代的流行瘟疫, 这项研究重建了新石器时代早期的疾病传播和社会结构.
科学领域:
- 古遗传学
- 古遗传学
- 流行病学
背景情况:
- 欧洲新石器时代的衰退 (5,3004,900年). 包括农业危机和疾病.
- 病原体,特别是瘟疫在人口变化中的作用尚不清楚.
研究的目的:
- 通过人口规模的古代基因组学来调查新石器时代衰退的原因.
- 重建新石器时代斯堪的纳维亚的病原体传播,社会组织和亲属关系结构.
主要方法:
- 对108名斯堪的纳维亚新石器时代个体的古老DNA进行分析.
- 人口规模的古代基因组学用于推断祖先和病原体感染.
- 基于变异图的泛基因组学用于重建瘟疫基因组和Yersinia伪结核病的演变.
主要成果:
- 新石器时代的瘟疫 (Yersinia pseudotuberculosis) 已经广泛蔓延,影响了至少17%的样本人口.
- 在大约120年的时间里, 瘟疫在三个不同的感染事件中传播.
- 四个多代血统的重建揭示了父系社会组织和女性外婚的证据.
结论:
- 古代基因组学提供了广泛传播的瘟疫的直接证据,
- 这项研究阐明了新石器时代瘟疫的传播动态及其对斯堪的纳维亚人口的影响.
- 这些发现为新石器时代的社会结构提供了洞察力,包括父系组织和婚姻模式.
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