可修改的风险因素与肝细胞癌之间的关联:一个跨祖先的门德尔随机化研究
Xiaoxia Wei1, Chenglei Yang2, Qiuling Lin1
1Department of Clinical Trial Base, Guangxi Medical University Cancer Hospital, Nanning, Guangxi, China.
BMC cancer
|July 10, 2024
概括
东亚和欧洲人群之间的肝细胞癌 (HCC) 风险因素不同. 然而,酸氨基转移酶 (AST) 和与代谢功能障碍相关的脂肪性肝病 (MASLD) 是常见的可修改风险,指导向的HCC预防策略.
科学领域:
- 遗传学和流行病学
- 肝细胞癌研究 肝细胞癌研究
- 公共卫生 公共卫生
背景情况:
- 观察性研究已经确定了东亚和欧洲人群中肝细胞癌 (HCC) 的潜在可改变的风险因素.
- 然而,许多这些HCC风险因素的因果关系仍然不清楚.
- 了解这些因果关系对于制定有效的预防策略至关重要.
研究的目的:
- 调查可修改风险因素与肝细胞癌 (HCC) 风险之间的因果关系.
- 为了比较东亚和欧洲人口之间的这些关联.
- 为了确定针对性HCC干预的共同和人群特异性风险因素.
主要方法:
- 在全基因组关联研究 (GWAS) 中,收集了22个东亚人和33个欧洲人的可修改风险因素的总结统计数据.
- 对HCC的遗传总结统计数据来自日本,冰岛和英国生物银行的大规模研究.
- 两个样本的门德尔随机化 (MR) 分析对每个人口进行了独立的分析.
主要成果:
- 在东亚人中,增加的HCC风险与基因预测的酒精频率,阿斯巴胺转移酶 (AST),甲状腺功能低下,慢性肝炎B和C,代谢功能障碍相关的脂肪性肝病 (MASLD) 和自身免疫性肝炎有关.
- 在欧洲人中,氨酸转胺酶,AST,MASLD,肝脂肪的百分比和肝脏铁含量与更高的HCC风险有显著的关联.
- 复制数据集和元分析证实了这些发现.
结论:
- 肝细胞癌 (HCC) 风险因素在东亚和欧洲人群之间存在差异.
- 在两种人群中都发现了常见的可修改风险因素,特别是AST和MASLD.
- 这些共同的风险因素为制定有效的,全民范围的HCC干预策略提供了有价值的目标,以减少疾病的社会负担.
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