基因营养相互作用与腰围相关的证据,横截面分析
Anwar H AlBaloul1,2, Jennifer Griffin2, Alexandra Kopytek2
1Department of Community Medicine and Behavioural Sciences, Faculty of Medicine, Kuwait University, Safat, Kuwait.
BMC public health
|July 10, 2024
概括
饮食质量和遗传风险得分与腰围有关,但基因-营养物相互作用似乎没有影响它. 这些发现可以帮助识别有高腰围和相关疾病风险的个体.
科学领域:
- 心血管健康 心血管健康
- 遗传学 是一个遗传学.
- 营养科学 营养科学
背景情况:
- 腰围 (WC) 是身体脂肪的关键指标,与心血管疾病死亡率和发病率有关.
- 以前的研究集中在单个营养素和基因上,对饮食质量和遗传风险评分对WC的影响的理解有限.
- 关于WC的基因营养相互作用在很大程度上仍未被探索.
研究的目的:
- 调查整体饮食质量和WC相关遗传风险评分对腰围的影响.
- 探索影响腰围的潜在基因营养相互作用.
主要方法:
- 两项大型英国人口研究 (空中波健康监测研究和英国生物银行队列研究) 的横截面分析.
- 使用梅伦指数评估饮食质量,以阻止高血压的饮食方法 (Mellen-DASH).
- 从与WC相关的单核酸多态度计算了WC (GRS-Waist) 的遗传风险得分;使用多变量回归模型分析关联和相互作用.
主要成果:
- 在研究群体中,高WC患病率为46.5%和51.7%.
- 饮食质量 (Mellen-DASH评分) 和遗传风险评分 (GRS-Waist) 都与WC有显著的关联.
- 没有发现GRS-Waist,DASH饮食得分和WC上的营养摄入量之间有显著的相互作用证据.
结论:
- 可复制的结果证实了饮食,遗传和WC之间的关联,构成了早期风险识别的基础.
- 研究结果表明,饮食和遗传学可以帮助识别有高WC和相关疾病风险的个体.
- 关于基因与饮食相互作用的有限证据需要进一步研究,以便在精密营养中应用.
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