系统治疗和放射治疗相关的并发症和随后的住院率:系统性审查
Rashidul Alam Mahumud1, Md Shahjalal2, Padam Kanta Dahal3
1NHMRC Clinical Trials Centre, Faculty of Medicine and Health, The University of Sydney, Camperdown, New South Wales (NSW), Australia.
BMC cancer
|July 10, 2024
概括
癌症治疗并发症,特别是组合疗法,经常导致住院治疗. 进一步的研究和医疗保健改进至关重要,以减少患者和医疗保健系统的负担.
科学领域:
- 在瘤学瘤学.
- 临床研究 临床研究
- 公共卫生 公共卫生
背景情况:
- 癌症疗法,包括全身疗法和放射疗法,可能会导致严重的并发症.
- 这些并发症导致患者,社会和医疗保健系统的重大负担.
- 了解并发症和住院之间的联系是预防和改善护理的关键.
研究的目的:
- 审查现有的关于全身和放射治疗癌症治疗并发症的文献.
- 评估这些并发症对住院率的影响.
- 确定常见的并发症和影响其发生的因素.
主要方法:
- 在PubMed,Scopus,Embase和谷歌学者 (2000-2023) 的系统文献搜索.
- 包括同行评审的研究,按并发症和住院影响分类.
- 评估方法质量,以解决研究异质性的问题.
主要成果:
- 包括25项涉及约3400万患者的研究 (21个队列,3个RCT,1个横截面).
- 常见的并发症包括中性质减退,心脏问题,吐,发烧和损伤.
- 组合疗法与更多的并发症有关;80%的研究报告了住院率,有些由于并发症超过50%甚至90%.
结论:
- 治疗后的并发症在各种癌症治疗模式中越来越令人担忧.
- 组合疗法具有更高的并发症风险.
- 缓解策略,进一步的研究和医疗保健系统的改进对于管理与治疗有关的住院治疗至关重要.
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