关于他类药物和金诺类药物之间的药物相互作用的系统审查
Jifang Zhou1, Lixia Yu2, Huimin Xu3
1Department of Pharmacy, First People's Hospital of Linping District, Hangzhou, China.
BMC pharmacology & toxicology
|July 10, 2024
概括
结合他类药物和类药物可以导致严重的肌肉损伤和肝脏问题. 密切监测肌肉症状和酶水平至关重要,特别是在患有脏疾病的老年患者或服用其他相互作用药物的患者中.
科学领域:
- 药理学 药理学是指药理学的学科.
- 药物相互作用 药物相互作用
- 心血管疾病管理管理
背景情况:
- 类药物是心血管疾病 (CVD) 的主要降脂剂.
- 昆诺是一种用于感染的抗生素.
- 同时使用他类药物和类药物是常见的,因为同时存在心血管疾病和感染.
研究的目的:
- 系统地审查关于他类药物和类药物相互作用的证据.
- 描述与这种药物组合相关的不良事件.
- 讨论他类醇治疗的风险减轻策略.
主要方法:
- 在PubMed,Embase,Scopus和Cochrane图书馆进行系统的文献审查.
- 搜索术语包括他类药物,类药物和药物相互作用.
- 对16个符合纳入标准的案例报告进行了定性分析.
主要成果:
- 分析了16份病例报告,其中最常见的不良事件 (n=12) 是拉布地质溶解.
- 西姆瓦斯塔丁和阿托瓦斯塔丁是最常见的他类药物;西普罗弗洛克萨和莱沃弗洛克萨是最常见的类药物.
- 高风险患者组包括60岁以上,患有脏疾病,以及使用CYP3A4,P-gp或OATP1B1抑制剂的患者.
结论:
- 类固醇和类固醇的同时使用需要对肌肉病变和肝毒性进行警监测.
- 建议对老年患者,患有功能障碍的患者以及服用特定他类药物 (simvastatin,高剂量阿托瓦斯塔丁) 和类药物 (ciprofloxacin,levofloxacin) 的个人特别谨慎.
- 建议对肌酸激酶 (CK) 和肝酶进行监测,以早期发现不良反应.
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