大脑动脉样硬化,缺口性心脏病发作和老年黑人成年人的认知能力
Debra A Fleischman1,2,3, Konstantinos Arfanakis1,4,5, Sue E Leurgans1,2,6
1Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois, USA.
概括
动脉样硬化和心脏病发作会影响老年黑人成年人的认知能力. 较高的动脉样硬化负载与更广泛的认知衰退有关,而心脏病发作特别影响工作记忆,突出了动脉样硬化作为潜在的痴呆症生物标志物.
科学领域:
- 神经学 神经学
- 老年学是指老年学的学科.
- 神经成像是一种神经成像.
背景情况:
- 大脑小血管疾病 (CSVD) 增加老年黑人成年人的痴呆风险.
- 动脉样硬化和缺血性缺口性心脏病发作是已知的影响认知的CSVD亚型.
- 这些CSVD亚型对该人群认知的综合影响仍然不清楚.
研究的目的:
- 调查动脉样硬化症 (ARTS) 和缺血性缺口性心脏病发作与老年黑人成年人的认知功能之间的联系.
- 确定这些CSVD亚型对认知水平和变化的差异和综合影响.
主要方法:
- 利用混合模型分析动脉样硬化和心脏病发作的体内测量.
- 评估了370名没有痴呆症的黑人老年人的认知水平和变化.
- 在ARTS和心脏病中采用磁共振成像衍生的测量方法.
主要成果:
- 较高的动脉样硬化负载与较低的全球认知,情节性记忆,语义记忆和感知速度有关.
- 较高的心脏病发作负载与较低的工作记忆相关.
- 两种CSVD亚型都没有与认知变化速度的关联.
结论:
- 动脉样硬化和心脏病发作都对老年黑人成年人的认知健康有重大影响.
- 动脉样硬化显示出对认知的更广泛的影响,并显示出作为痴呆风险的体内生物标志物具有前途.
- 在黑人人口中进行进一步的体内研究对于了解CSVD亚型和认知健康至关重要.
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