从叶参与到前性痴呆的社会情绪功能障碍:初步报告
Kelsey A Holiday1, Alexander Sheppard1, Youssef I Khattab1
1Veterans Administration Greater Los Angeles Healthcare System, Los Angeles (Holiday, Khattab, Chavez, Melrose, Mendez); Department of Neurology, University of California, Los Angeles (UCLA) (Holiday, Sheppard, Khattab, Chavez, Mendez); Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA (Melrose, Mendez).
概括
行为变异前性痴呆症 (bvFTD) 与由右前叶缩引起的社会情绪变化有关. 早期发病的阿尔茨海默氏病 (EOAD) 也表现出社会情绪变化,与右侧头皮层缩有关.
科学领域:
- 神经科学是一个神经科学.
- 神经学 神经学
- 神经成像是一种神经成像.
背景情况:
- 行为变异前性痴呆症 (bvFTD) 的特点是社会情绪变化,通常归因于前叶功能障碍.
- 新出现的证据表明,右前叶疾病在这些社会情绪变化中起着作用.
- 在bvFTD和早期阿尔茨海默病 (EOAD) 中,社会情绪功能障碍的神经解剖学基础需要进一步调查.
研究的目的:
- 评估bvFTD和EOAD患者区域性脑缩和社会情绪变化之间的关系.
- 通过社会情绪功能障碍量表 (SDS) 测量,确定与社会情绪功能障碍相关的特定大脑区域.
主要方法:
- 该研究包括13名bvFTD患者和16名年龄匹配的EOAD患者.
- 基于MRI图像的张量体分析被用来评估区域大脑体积.
- 社会情绪功能障碍量 (SDS) 评分与区域大脑体积相关.
主要成果:
- 与EOAD患者相比,bvFTD患者的SDS得分更高,前部区域更小.
- 在bvFTD中,SDS得分与侧前叶 (ATL) 缩有显著的相关性.
- 在bvFTD中,较高的SDS得分与横向/右侧ATL和轨道前皮层的缩有关;在EOAD中,较高的SDS得分与右头皮层缩有关.
结论:
- bvFTD的社会情绪变化源于轨道前和突出的右侧ATL疾病.
- 左右头顶皮层的参与可能会导致EOAD中观察到的社会情绪变化.
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