以贝为灵感的水溶性组织粘合剂的生物相容性
Aishwarya V Menon1,2, Amelia A Putnam-Neeb2, Caitlin E Brown3
1Davidson School of Chemical Engineering, Purdue University, West Lafayette, Indiana, USA.
Journal of biomedical materials research. Part A
|July 11, 2024
概括
这项研究评估了一种新的基于catechol的共聚合物粘合剂,用于伤口关闭. 虽然粘合剂随着时间的推移减少了炎症,但交叉链接版本在小鼠中引起了持续的中度炎症.
科学领域:
- 生物材料科学 生物材料科学
- 聚合物化学 聚合物化学
- 手术创新 在外科创新.
背景情况:
- 传统的手术伤口关闭方法,如和是侵入性的.
- 组织粘合剂提供更容易的应用,但需要提高毒性,湿粘强度和长期粘合.
- катехол化学为开发先进的湿粘组织粘合剂提供了一个有前途的途径.
研究的目的:
- 评估一种新型水溶性甲基聚合物基聚合物粘合剂,聚甲基-MMA-OEG的生物相容性和长期组织反应.
- 为了比较单独的共聚合物粘合剂与与酸盐交叉连接剂结合的生物相容性.
- 在皮下小鼠模型中评估粘合剂配方的炎症反应和降解概况.
主要方法:
- 一种基于catechol的共聚合物,poly ((catechol-MMA-OEG) 被合成并配制成一种潜在的组织粘合剂.
- 粘合剂在小鼠体内进行皮下注射,单独和与酸盐交叉连接剂一起.
- 在注射后72小时,4周和12周进行了组织病理学分析,以评估组织反应和降解.
主要成果:
- 无论是聚甲基-MMA-OEG粘合剂还是其交叉连接的对应物,在12周后仍然是可触摸的,这表明降解速度缓慢.
- 聚甲醇-MMA-OEG组在72小时后的炎症从中度降低到12周后轻度降低.
- 聚甲醇-MMA-OEG) +交叉链接组在12周后表现出持续的中度炎症反应,这种反应在最初的72小时观察后没有减弱.
结论:
- 基于catechol的共聚合物粘合剂显示了可接受的生物相容性,在12周内炎症反应减少.
- 添加 sodium periodate 交叉连接剂可能会导致长时间的炎症反应,这表明这种特定配方的潜在限制.
- 对优化交叉连接策略或替代配方的进一步研究是有必要的,以提高组织粘合性能和减少不良组织反应.
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