亚齐思罗米的使用可归因于急性SARS-CoV-2感染
Carlo Gagliotti1,2, Federico Banchelli1,2, Rossella Buttazzi1,2
1Department of Innovation in Healthcare and Social Services, Emilia-Romagna Region, Bologna, Italy.
Pharmacoepidemiology and drug safety
|July 11, 2024
概括
早期COVID-19 (SARS-CoV-2) 治疗错误信息导致阿齐思罗米辛的处方增加. 这项研究发现,在急性感染阶段,抗生素使用量显著增加,这表明处方做法不当.
科学领域:
- 传染性疾病 传染性疾病
- 药理学 药理学是指药理学的学科.
- 公共卫生 公共卫生
背景情况:
- 初步的,后来被驳斥的发现表明阿齐思罗米对SARS-CoV-2的疗效.
- 这导致了COVID-19大流行期间抗生素的潜在过度处方.
- 缺乏关于在急性SARS-CoV-2感染中使用阿兹罗密辛的个人级别数据.
研究的目的:
- 分析个人层面的数据,将阿齐思罗米使用与急性SARS-CoV-2感染联系起来.
- 在SARS-CoV-2感染的不同阶段量化阿兹罗米辛的消耗.
- 评估病毒变异对抗生素处方模式的影响.
主要方法:
- 基于人口的回顾性队列研究 (2020年2月至2022年2月).
- 利用来自意大利埃米利亚-罗曼尼亚地区的门诊处方数据.
- 在急性,后急性和控制期中比较阿齐思罗米辛消耗 (DDD),按SARS-CoV-2变种分层.
主要成果:
- 在所有变种的急性SARS-CoV-2阶段,阿兹罗密辛消费率 (每1000个人/天的DDD) 显著增加.
- 接受阿齐思罗米的个体的百分比和其在总抗生素使用中的份额也增加了.
- 在后急性阶段,消费量恢复到基线水平;12.9%的阿齐思罗米辛总消费量与急性COVID-19有关.
结论:
- 在急性SARS-CoV-2感染期间,阿齐思罗米辛的处方增加表明使用不当.
- 在大多数情况下,细菌共感染的可能性较低进一步支持了这一结论.
- 强调在公共卫生危机期间需要基于证据的处方.
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