细胞中NAD (H) 和NADP (H) 的稳态调节
Luojun Chen1, Xiaoke Xing1,2, Pingfeng Zhang1
1Cancer Center, Renmin Hospital of Wuhan University, Wuhan, Hubei 430062, China.
Genes & diseases
|July 11, 2024
概括
维持细胞能量平衡至关重要. 尼古丁胺氨基二核酸 (NAD) 和尼古丁胺氨基二核酸 (NADP) 水平由特定的酶调节,它们的不平衡与癌症等疾病有关.
科学领域:
- 生物化学 生物化学
- 细胞的新陈代谢
- 分子生物学分子生物学
背景情况:
- 尼古丁胺胺氨基二核酸 (NAD) 和尼古丁胺胺氨基二核酸 (NADP) 是调节许多代谢途径的必不可少的共酶.
- NAD (((H) 对于代谢反应至关重要,而NADP (((H) 则支持代谢和抗氧化剂防御.
- NAD(H) 和NADP(H) 的稳态对于细胞功能至关重要,并且受到严格的调节.
研究的目的:
- 审查NAD (H) 和NADP (H) 的生理作用.
- 讨论NAD (H) /NADP (H) 稳态的调节机制,重点关注NAD激酶 (NADK) 和NADP (H) 酸酶 (MESH1,NOCT).
- 探索昼夜时钟对NAD (H) /NADP (H) 恒温的影响.
主要方法:
- 关于NAD (H) /NADP (H) 代谢和调节的文献综述.
- 对NADKs的转录和翻译后调节的分析.
- 检查MESH1和NOCT在NAD (H) /NADP (H) 转换中的作用.
- 研究昼夜时钟对NAD (H) /NADP (H) 恒温的影响.
主要成果:
- NADKs从NAD+合成NADP+,而MESH1和NOCT则将NADP (H) 转化为NADP (H).
- NADKs的转录和翻译后修改微调NADP+水平.
- MESH1和NOCT是NAD (H) /NADP (H) 氧化还原平衡的关键调节者.
- 昼夜时钟影响NAD (H) 和NADP (H) 稳态,影响细胞过程.
结论:
- NADKs,MESH1和NOCT对于维持NAD (H) /NADP (H) 稳态至关重要.
- 这些酶的失调与癌症和代谢障碍等疾病有关.
- 准这些酶为恢复代谢平衡提供了潜在的治疗策略.
更多相关视频
05:27Inner Mitochondrial Membrane Sensitivity to Na+ Reveals Partially Segmented Functional CoQ Pools
Published on: July 20, 2022
1.9K
05:58A Novel Nicotinamide Adenine Dinucleotide Correction Method for Intracellular Ca2+ Measurement with Fura-2-Analog in Live Cells
Published on: September 20, 2019
6.7K
相关概念视频
pH Regulation in Cells
6.0K
pH plays a critical role in maintaining normal cellular activities. It helps maintain the structure and function of various proteins, dictates the charge on cellular membranes, and is crucial for metabolic reactions inside the cell. Moreover, cells use the energy from the proton motive force to generate ATP.
Cytosolic pH
Under physiological conditions, the cytosolic pH is slightly more acidic than the extracellular pH. However, cells must prevent further acidification of their cytosol to...
Cytosolic pH
Under physiological conditions, the cytosolic pH is slightly more acidic than the extracellular pH. However, cells must prevent further acidification of their cytosol to...
6.0K
Role of Reduced Coenzymes NADH and FADH₂
11.3K
The energy released from the breakdown of the chemical bonds within nutrients can be stored either through the reduction of electron carriers or in the bonds of adenosine triphosphate (ATP). In living systems, a small class of compounds functions as mobile electron carriers, molecules that bind to and shuttle high-energy electrons between compounds in pathways. The principal electron carriers that will be considered originate from the B vitamin group and are derivatives of nucleotides; they are...
11.3K
pH Homeostasis
12.6K
Acid-base homeostasis is essential for maintaining normal physiological activities in humans. The pH of various body fluids is strictly regulated because it is critical for the optimal activity of enzymes involved in metabolic reactions. Enzymes are basically proteins, so, any significant change in pH can affect their structure and activity. In humans, pH is regulated using three primary mechanisms— chemical buffer systems, respiratory regulation, and renal regulation.
Respiratory...
Respiratory...
12.6K
Regulation of Metabolism
9.3K
Cellular needs and conditions vary from cell to cell and change within individual cells over time. For example, the required enzymes and energetic demands of stomach cells are different from those of fat storage cells, skin cells, blood cells, and nerve cells. Furthermore, a digestive cell works much harder to process and break down nutrients during the time that closely follows a meal compared with many hours after a meal. As these cellular demands and conditions vary, so do the amounts and...
9.3K
What is Homeostasis?
37.1K
Maintaining homeostasis requires that the body continuously maintain its internal conditions. Each physiological condition has a particular set point, from body temperature to blood pressure to levels of certain nutrients. A set point is the physiological value around which the normal range fluctuates. A normal range is a restricted set of values that is optimally healthful and stable. For example, the set point for normal human body temperature is approximately 37°C (98.6°F).
37.1K
Renal Regulation of Acid-Base Balance
388
Metabolic reactions in the body produce nonvolatile acids, such as sulfuric acid, which generate an acid load of approximately 1 mEq of H+ per kilogram of body weight daily. Excreting H+ in the urine is essential to balance this acid load.
In the kidneys, cells within the proximal convoluted tubules (PCT) and the collecting ducts secrete hydrogen ions (H+) into the tubular fluid. Specifically, in the PCT, Na+/H+ antiporters secrete H+ while reabsorbing Na+.
However, the intercalated cells in...
In the kidneys, cells within the proximal convoluted tubules (PCT) and the collecting ducts secrete hydrogen ions (H+) into the tubular fluid. Specifically, in the PCT, Na+/H+ antiporters secrete H+ while reabsorbing Na+.
However, the intercalated cells in...
388
