对比预防性氧化,迪克洛菲纳克和 gabapentin 在骨骨折手术后术后疼痛的影响: 一个随机的临床轨道
Ramin Abrishami1, Mehri Farhang Ranjbar1, Amirreza Modir2
1Research Center for Trauma in Police Operations, Directorate of Health, Rescue & Treatment, Police Headquarter, Tehran, Iran.
Journal of the West African College of Surgeons
|July 11, 2024
概括
预防性使用氧化,迪克洛菲纳克和 gabapentin 有效地管理骨骨折患者的术后疼痛. 加巴丁在手术后6小时显示出更大的疼痛缓解潜力.
科学领域:
- 麻醉学 麻醉学
- 整形外科手术 整形外科手术
- 药理学 药理学是指药理学的学科.
背景情况:
- 手术后疼痛 (POP) 是手术后的一大临床挑战.
- 有效的疼痛管理对于患者的康复和福祉至关重要.
研究的目的:
- 为了比较预防性氧化,迪克洛菲纳克和 gabapentin 在骨骨折手术后管理 POP 的疗效.
- 评估这些止痛药对疼痛评分和镇静水平的影响.
主要方法:
- 一个双盲,三组随机对照试验,涉及111名接受骨骨折手术的患者.
- 患者被随机分配给接受预防性氧化,迪克洛芬雅克或 gabapentin.
- 疼痛,镇静和阿片类药物使用被评估在多个时间点,直到手术后24小时.
主要成果:
- 在各组之间没有观察到人口统计和临床特征的显著基线差异.
- 总的来说,POP和镇静水平在各组之间没有显著差异,除了手术后6小时.
- 在6小时标记下, gabapentin与氧化和迪克洛芬雅克相比,在统计学上显著地减少了POP (P=0.001).
- 手术后的阿片类药物消费和药物副作用在所有组中都是可比的.
结论:
- 在骨骨折手术后,预防性使用氧化,迪克洛菲纳克和 gabapentin 有效地减少了 POP.
- 加巴丁可能在特定的术后间隔提供优越的止痛作用.
- 选择先发性止痛药应根据临床判断进行个性化选择.
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