神经性厌食症女性的psilocybin治疗:第一阶段,开放标签可行性研究
Stephanie Knatz Peck1, Samantha Shao1, Tessa Gruen1
1Department of Psychiatry, Eating Disorder Treatment & Research Center, University of California, San Diego, San Diego, CA, USA (all authors); University of Michigan Medical School, Ann Arbor, MI, USA (Gruen).
概括
псилоцибин治疗显示承诺作为一个安全和可接受的治疗精神性厌食症 (AN) 在成年女性. 这项可行性研究发现,该疗法耐受性良好,没有显著的不良事件,这表明AN治疗的潜在新途径.
科学领域:
- 心理药理学 心理药理学
- 临床心理学 临床心理学
- 饮食障碍 研究 研究 研究
背景情况:
- 神经性厌食症 (AN) 是一种严重的饮食障碍,有效治疗方法有限.
- 迫切需要新的治疗干预措施来改善AN的结果.
- 目前的治疗选择缺乏FDA批准的用于核心AN症状的药物.
研究的目的:
- 评估成年妇女与AN或部分AN (pAN) 的psilocybin治疗的安全性,耐受性和可行性.
- 为了评估治疗后的不良事件 (AEs) 和生命体征变化,心电图,实验室测试和自杀倾向.
- 探索参与者对新型治疗方法的定性感知.
主要方法:
- 开放式可行性研究,涉及10名符合DSM-5标准的成年女性参与者.
- 单剂量25毫克的合成psilocybin与心理支持相结合.
- 通过AE,心电图,实验室测试,生命体征和自杀性评估,系统地监测安全性和耐受性.
主要成果:
- 发现在psilocybin治疗是安全和耐受,所有的AEs是轻微的和短暂的.
- 在心电图,生命体征或自杀性评估中没有观察到临床显著的变化.
- 两名参与者经历了无症状低血糖症,在24小时内消失,没有其他显著的实验室异常.
结论:
- 对于神经性厌食症的女性来说,psilocybin治疗似乎是一种安全,耐受和可接受的治疗选择.
- 这些发现对开发AN新疗法战略充满希望,解决关键的未满足需求.
- 这项研究强调了西辅助治疗在具有显著生理风险和治疗参与挑战的人群中的潜力.
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