饮食障碍遗传学接下来会发生什么? 用事实取代神话,提高我们的理解
Laura M Huckins1, Rebecca Signer1, Jessica Johnson1
1Pamela Sklar Division of Psychiatric Genomics, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA (Huckins, Signer, Johnson); Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA (Huckins, Signer); Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Mental Illness Research, Education and Clinical Centers, James J. Peters Department of Veterans Affairs Medical Center, Bronx, NY 14068, USA (Huckins); School of Nursing, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA (Wu); Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA (Wu, Bulik); National Center for PTSD at VA Boston Healthcare System, Boston, MA, USA; Department of Psychiatry, Boston University School of Medicine, Boston, MA, USA (Mitchell); Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; Department of Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA (Bulik).
饮食障碍 (ED) 遗传学研究已经取得了进展,但缺乏包容性. 本综述解决了历史上的偏见,并提出了更多多样化和可翻译的ED遗传研究的策略.
科学领域:
- 遗传学 是一个遗传学.
- 精神病学是一个精神病学.
- 饮食障碍 饮食障碍 饮食障碍 饮食障碍
背景情况:
- 大规模的联盟已经确定了厌食症神经障碍 (AN) 和其他饮食障碍 (ED) 的全基因组显著的位置和基因.
- 目前的研究受限于狭的重点,导致误解和排除不同患者群体.
- 历史上的偏见导致对ED表现和各种人口统计学基因基础的不完全理解.
研究的目的:
- 为了抵消饮食障碍 (ED) 遗传学研究的历史不平衡.
- 审查目前对ED遗传基础的理解,在不同的人群中.
- 提出设计更具包容性和临床可翻译性遗传研究的策略.
主要方法:
- 关于饮食障碍 (ED) 遗传学的现有文献的审查.
- 关于不同人口群体 (性别,年龄,种族,种族,身体形状/体重,性取向,社会经济地位) 的遗传基础的分析.
- 讨论包容性研究设计和研究目标扩展的战略.
主要成果:
- 在识别AN和ED遗传位点和基因方面取得了重大进展.
- 现有的研究还没有充分代表多样化的群体,这阻碍了概括性.
- 需要解决刻板印象和误解,以改善对ED的理解.
结论:
- 包容性研究对于推进对饮食障碍 (ED) 遗传学的理解至关重要.
- 扩大研究的多样性将提高遗传见解的临床可翻译性.
- 未来的战略应该集中在扩大ED遗传研究的范围,以涵盖所有受影响的个体.
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