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神经omyelitis光学谱系障碍与急性脑干表现作为最初的症状

Zhen Li¹, Minggang Yang², Yang Pan³

¹Department of Neurology, The First Affiliated Hospital of Soochow University, Suzhou, 215006, China.

|July 11, 2024

概括

神经omyelitis optica光谱障碍 (NMOSD) 最初可能出现脑干症状,导致高早期误诊率和复发率增加. 老年患者或最初在非神经病学部门看到的患者更容易被误诊.

科学领域:

神经学神经学
免疫学免疫学免疫学
神经免疫学神经免疫学

背景情况:

神经脊髓炎光学谱系障碍 (NMOSD) 是一种罕见的自身免疫性疾病,向中枢神经系统.
脑干表现可能是NMOSD的初始表现,这给诊断带来了挑战.

研究的目的:

为了调查NMOSD患者的临床特征和预后,初始急性脑干症状.
将这些患者与其他初始症状的患者进行比较.

主要方法:

从两个医疗中心的NMOSD患者的临床数据的回顾性分析.
将NMOSD与脑干表现作为初始症状 (NMOSD-BSMIS) 和NMOSD与其他初始表现 (NMOSD-OMIS) 之间的临床特征,神经成像和预后进行比较.

主要成果:

在283名NMOSD患者中,52名 (18.37%) 最初出现了急性脑干症状.
常见的初始症状包括恶心,吐,打,双眼视,,头痛和面部低感觉. 在81.63%的测试患者中,水素4 (AQP4) -IgG抗体呈阳性.
在NMOSD-BSMIS的早期误诊率为46.15%. 年龄较大和初次入院非神经病学部门与更高的误诊率有关. 与NMOSD-OMIS患者相比,NMOSD-BSMIS患者的每年复发率明显高.

结论:

NMOSD可以呈现出各种各样的初始脑干症状,往往导致诊断延迟.
误诊的风险因素包括年龄较大和初始的非神经学咨询.
具有初始脑干症状的NMOSD表现出更高的年初复发率,强调需要及时识别和管理.

关键词:

大脑干症状脑干症状一个错误的诊断.视觉神经炎光学谱系障碍复发复发的情况

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