增长分化因子15 (GDF-15) 血清水平与2型糖尿病的基因多态性之间的相关性
Qiumei Liu1, Lidong Qin1, Yujian Liang1
1Department of Occupational and Environmental Health, School of Public Health, Guangxi Medical University, Nanning, China.
Heliyon
|July 11, 2024
概括
增长差异化因子15 (GDF-15) 水平和特定基因变异与2型糖尿病 (T2DM) 风险有关. GDF-15 rs1054564基因型与中国农村人口的T2DM风险增加有关.
科学领域:
- 遗传学和分子生物学
- 内分泌学和新陈代谢学
- 人口健康 人口健康
背景情况:
- 增长差异化因子15 (GDF-15) 基因多态和2型糖尿病 (T2DM) 风险之间的关系尚不清楚.
- 研究GDF-15在T2DM病原体中的作用对于了解疾病机制至关重要.
研究的目的:
- 探索血清GDF-15水平和GDF-15基因多态与T2DM风险之间的关联.
- 在中国农村的族人群中分析这些关联.
主要方法:
- 一个1: 1病例控制研究,涉及179名T2DM患者和179名匹配对照.
- 血清GDF-15水平使用酶相关免疫吸收试验量化.
- 通过MassArray质谱测量进行了GDF-15基因多态 (rs1059519,rs1059369,rs1804826,rs1054564) 的基因定型.
主要成果:
- 与对照组相比,T2DM患者 (HbA1c ≥6.5%) 的血清GDF-15水平显著更高 (p < 0.001).
- 血清GDF-15与禁食血葡萄糖 (FPG) 和糖化血红蛋白 (HbA1c) 有积极的相关性.
- GDF-15 rs1054564 GC+CC基因型与增加的T2DM风险 (OR=1.724,p=0.033) 有关. 在rs1059519 C等位基因表现出与FPG和HbA1c的负相关性.
结论:
- 血清GDF-15水平与血糖控制标志物 (FPG,HbA1c) 有积极的关联.
- 在这个人群中,GDF-15 rs1054564基因型是T2DM的潜在风险因素.
- rs1059519 C等位基因可能对高血糖有保护作用.
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