新诊断多发性硬化症患者的甲状腺自身抗体:一个横截面研究
Maryam Poursadeghfard1, Arashk Mallahzadeh1, Ava Hamidi1
1Clinical Neurology Research Center Shiraz University of Medical Sciences Shiraz Iran.
Health science reports
|July 11, 2024
概括
多发性硬化症患者显示甲状腺功能障碍的患病率较高,特别是改变了TSH水平. 这表明MS患者甲状腺问题的风险增加,需要进一步调查.
科学领域:
- 神经学 神经学
- 内分泌学 在内分泌学.
- 免疫学 免疫学 免疫学
背景情况:
- 多发性硬化症 (MS) 是一种慢性中枢神经系统炎症性疾病.
- 自身免疫性甲状腺疾病是MS的常见并发症.
- 甲状腺激素对大脑功能和复髓化至关重要.
研究的目的:
- 为了确定甲状腺功能障碍在新诊断的多发性硬化症患者中的患病率.
- 为了比较MS患者的甲状腺功能与健康对照.
- 调查年龄,甲状腺激素和MS中的抗体之间的关系.
主要方法:
- 在伊朗的雪拉兹进行了横截面研究.
- 包括73名新诊断的,未经治疗的多发性硬化症患者和72名健康对照.
- 测量了血清中的TSH,抗TPO-Ab和抗TG-Ab水平.
主要成果:
- 在MS患者中异常TSH水平的显著更高的患病率 (p=0.02).
- 在女性多发性硬化患者中观察到甲状腺功能障碍的频率增加 (p=0.01).
- 在MS患者中发现年龄和TSH/Anti-TPO-Ab水平之间的正线性关系.
结论:
- 多发性硬化症患者的TSH变化患病率较高,这表明甲状腺功能障碍的风险可能增加.
- 抗TPO-Ab和抗TG-Ab水平在不同组之间没有显著差异.
- 需要进一步的研究来阐明MS中甲状腺功能障碍的潜在原因.
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