在CBA/J小鼠中,与年龄有关的变化影响了中介性橄耳外毛细胞和初级听力带突触
Nele Marie Dörje1,2, Liana Shvachiy3,4,5, Fabian Kück6
1University Medical Center Göttingen, Department of Otolaryngology-Head and Neck Surgery, InnerEarLab, Göttingen, Germany.
Frontiers in cellular neuroscience
|July 11, 2024
概括
老龄化听力损失是很常见的. 这项研究发现,在老龄化CBA/J小鼠中,保护性传导性中介性橄耳 (MOC) 突触比传导性内毛细胞突触晚衰.
科学领域:
- 听觉神经科学 听觉神经科学
- 衰老研究研究 衰老研究
- 感官生理学 感官生理学
背景情况:
- 听力下降是衰老中最常见的感官缺陷.
- 有效的听觉系统可以提供对与年龄相关的听力损失的保护.
- 中间橄耳 (MOC) MOC无突触调节外毛细胞 (OHC) 的活动.
研究的目的:
- 描述不同MOC-OHC突触中的与年龄相关的变化.
- 为了比较这些变化与 afferent内毛细胞 (IHC) 带突触的年龄相关变化.
- 为了研究CBA/J小鼠在生命周期中的这些变化.
主要方法:
- 从年轻 (3个月大) 和老年 (10-20个月大) CBA/J小鼠中比较Corti的器官.
- 分析了一只耳朵的有机MOC-OHC突触和对侧耳朵的有机IHC-SGN突触.
- 检查了分别的耳转向 (顶端,中间,基底).
主要成果:
- 在14个月 (基底转变),16个月 (中间转变) 和18个月 (尖端转变) 开始时,异性IHC-SGN突触显著下降.
- 有效的MOC-OHC突触显示出不那么明显的与年龄相关的损失.
- 只有在基底和中间耳转20个月后才观察到MOC-OHC突触的显著损失.
结论:
- 在CBA/J小鼠中,OHCs的efferent MOC 内化与年龄相关的减少开始于20个月.
- 有机MOC-OHC突触的形态衰退比有机IHC-SGN突触的衰退晚发生.
- 这表明efferent系统在缓解与年龄相关的听力下降方面可能起着保护作用.
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