在第三阶段/乙级牙周病中,microRNA-223/Ras关联结合蛋白12轴的表达动态:病例对照分析
Dhathri Priya Bandi1, Uma Sudhakar1, Harinath Parthasarathy2
1Department of Periodontology, Thaimoogambigai Dental College and Hospital, M.G.R. Educational and Research Institute, Kattankulathur, Chennai, Tamil Nadu, India.
Journal of Indian Society of Periodontology
|July 11, 2024
概括
在牙周病患者中,microRNA-223和RAB12基因表达显著增加,这表明它在疾病发病过程中起作用,并有可能作为诊断生物标志物.
科学领域:
- 口腔生物学 口腔生物学
- 分子生物学分子生物学
- 免疫学 免疫学 免疫学
背景情况:
- 牙周病源于微生物菌群和免疫反应.
- 细胞死亡途径和信号显著影响牙周炎的进展.
- 假设miR-223/RAB12轴在牙周炎中调节自性诱导的炎症.
研究的目的:
- 在第三阶段/B级牙周病中研究miR-223和RAB12表达.
- 探索miR-223/RAB12信号轴在牙周炎病理生理学中的作用.
主要方法:
- 在基中分析miRNA-223的目标.
- 在真实时间PCR分析miR-223和RAB12在牙裂液 (GCF).
- 包括50名健康对照和50名牙周病患者.
主要成果:
- 已确定RAB12为miR-223.3的目标基因.
- 在牙周病患者中显著增加miR-223 (15.21倍) 和RAB12 (34.70倍) 表达 (P<0.05).
- 接收器操作特征分析表明miR-223作为一个潜在的生物标志物,准确度为76% (AUC=0.777,P <0.01).
结论:
- 在GCF中升高的miR-223和RAB12表明参与牙周病的发病因子.
- miR-223/RAB12轴可能调节牙周组织中的自和烧.
- 这个轴在牙周病的病理生理学中呈现出一个潜在的联系.
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