性别失调青少年的青春期抑制:一个具有多重影响的新兴问题
Grigoria Betsi1, Panagiota Goulia2, Sophia Sandhu3
1Endocrinology and Diabetes Clinic, University Hospital of Heraklion, University of Crete School of Medicine, Heraklion, Greece.
Frontiers in endocrinology
|July 11, 2024
概括
在患有性别障碍症的青少年中使用GnRH类似物抑制青春期可能会改善幸福感,但会带来诸如骨积累减少等风险. 需要更多的研究来确认益处和安全性.
科学领域:
- 儿科内分泌学 儿科内分泌学
- 青少年精神病学 青少年精神病学
- 生殖医学 生殖医学
背景情况:
- 性别失调症 (GD) 的青春期抑制 (PS) 是有争议的.
- GnRH类似物 (GnRHa) 是PS的主要方法.
- 潜在的好处包括改善心理功能和延长诊断时间.
研究的目的:
- 审查目前关于GnRH类似物在患有性别失调的青少年中抑制青春期的疗效和安全性的证据.
- 确定与这种治疗相关的潜在好处和风险.
主要方法:
- 对GD的GNRH类比治疗现有科学文献的综述.
- 对关于心理健康,身体发育和副作用的报告结果的分析.
主要成果:
- GnRHa可以改善心理健康,延迟不可逆转的身体变化.
- 潜在的不良影响包括骨质积累受损,生长减速和脂肪质量增加.
- 像热这样的常见副作用通常是轻微的.
结论:
- 在被诊断为GD和严重痛苦的青少年中,可以考虑使用GNRHa的PS.
- 目前的证据仅限于小型,短期和不受控制的研究.
- 进一步的大规模,长期随机对照试验对于确定有效性和安全性至关重要.
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