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相关概念视频

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Genomics

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Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
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Author Spotlight: Integrating Organoid Models with Single-Cell and Spatial Transcriptomics Technologies
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从转录组学到器官功能的数字双胞胎.

Jens Hansen1, Abhinav R Jain1, Philip Nenov1,2

  • 1Department of Pharmacological Science and Institute for Systems Biomedicine, Icahn School of Medicine at Mount Sinai, New York, NY, United States.

Frontiers in cell and developmental biology
|July 11, 2024
PubMed
概括

这项研究引入了一个计算管道,将基因表达数据与动态模型联系起来,以预测细胞和器官功能. 这种方法可以创建器官的数字双胞胎,从而实现精准医学的预测.

关键词:
数字双胞胎数字双胞胎是什么意思动态建模的动态建模网络 网络 网络 网络 网络 网络系统生物学 系统生物学翻译学 翻译学 翻译学 翻译学

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科学领域:

  • 系统生物学 系统生物学
  • 计算生物学是一种计算生物学.
  • 基因组学就是基因组学.

背景情况:

  • 细胞功能是器官生理学的基础,基因表达模式揭示了细胞过程.
  • 单细胞转录组学为各种细胞类型及其比例中的基因表达提供了详细的见解.
  • 将基因表达与通路知识相结合,可以识别控制细胞功能 (如生长和分泌) 的网络.

研究的目的:

  • 开发一条用于将基因表达时间线与微分方程模型集成的计算管道.
  • 为了生成细胞类型特定的动态模型来模拟生理动态.
  • 创建预测模型,将基因组数据与器官功能联系起来,用于精准医学.

主要方法:

  • 开发了一个集成基因表达时间线和合微分方程系统的计算管道.
  • 生成了细胞类型选择性的动态模型.
  • 在巨细胞中测试了eicosanoid生物合成网络的管道.

主要成果:

  • 成功预测了巨细胞中的前列腺素和血栓合成和分泌动态.
  • 模型预测与实验性脂管学数据保持一致.
  • 证明了从转录基因数据中模拟全细胞功能输出的潜力.

结论:

  • 开发的管道使得能够创建细胞水平的系统生物学模拟.
  • 与知识图和多域本体学的集成可以将基因组决定因素与器官表型联系起来.
  • 这些数字双胞胎模型可以预测精准医学应用中的健康和疾病状态.