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在患有食道癌症的患者中,全身炎症评分的预后值
Akira Yoneda1, Ryosuke Ogata1, Shintaro Ryu1
1Department of Surgery, NHO Nagasaki Medical Center, Omura, Nagasaki, Japan.
Annals of medicine and surgery (2012)
|July 11, 2024
概括
系统性炎症评分 (SIS) 是一种结合淋巴细胞与单细胞比率和白蛋白的新型标记,可预测食道癌患者的复发和存活率. 较高的SIS分数表明预后较差,有助于临床决策.
科学领域:
- 在瘤学瘤学.
- 炎症标志物是一种炎症标志物.
- 预测指标 预测指标
背景情况:
- 系统性炎症评分 (SIS) 结合了淋巴细胞与单细胞比率 (LMR) 和血清白蛋白.
- SIS已经在各种癌症中显示出预后价值.
- 它在食道癌切除后的实用性需要澄清.
研究的目的:
- 评估SIS在接受潜在的治愈切除术的食道癌患者的预后价值.
- 将SIS与NLR和PNI等其他炎症标志物进行比较.
主要方法:
- 32名食道癌患者的回顾性队列研究.
- 从新辅助化疗前取的血液样本中分析SIS,NLR和PNI.
- 卡普兰-梅尔和考克斯回归模型用于评估无疾病生存率.
主要成果:
- 1或2的SIS分数与复发有显著的相关性 (HR 1.98).
- 较高的SIS分数与明显较差的生存率相关.
- NLR和PNI没有与复发或生存有显著的关联.
结论:
- SIS是食道癌患者手术后的独立预后因素.
- 当被整合到临床算法中时,SIS可以提高预后准确性.
- 对于这个患者群体来说,SIS提供了一种有价值,易于获得的预后工具.
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