疫苗接种对多发性硬化症患者COVID-19感染症状的影响
Parisa Sharifi1, Nasim Rezaeimanesh1, Amir Moradi2
1Multiple Sclerosis Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran.
eNeurologicalSci
|July 11, 2024
概括
在多发性硬化症 (MS) 患者中,COVID-19疫苗接种显著减少了呼吸道症状和头痛. 这凸显了疫苗接种对多发性硬化患者的好处,特别是那些服用免疫抑制药物的患者.
科学领域:
- 免疫学 免疫学 免疫学
- 神经学 神经学
- 传染性疾病 传染性疾病
背景情况:
- 多发性硬化症 (MS) 患者因疾病修饰疗法而面临感染风险增加.
- 评估COVID-19疫苗接种对MS患者感染症状的影响至关重要.
研究的目的:
- 评估COVID-19疫苗接种对伊朗多发性硬化症患者在COVID-19感染期间经历的症状的影响.
- 分析MS患者疫苗接种状态和COVID-19症状严重程度之间的关联.
主要方法:
- 一项涉及确认多发性硬化症患者的横截面研究.
- 通过在线问卷收集的数据包括人口统计数据,MS特征,COVID-19感染细节和疫苗接种状态.
- 使用COVID-19疫苗接种卡验证了疫苗接种状态.
主要成果:
- 共有236名多发性硬化患者参与了这项研究,72.5%的患者在第一次COVID-19感染之前接种了疫苗.
- 接种疫苗的多发性硬化患者的呼吸系统症状 (P=0.01) 和头痛 (P=0.04) 发生率显著降低.
- 在接种疫苗的人群中,逻辑回归表明呼吸系统症状 (OR=0.29) 和头痛 (OR=0.50) 的几率较低.
结论:
- 在感染期间,COVID-19疫苗接种有效减少多发性硬化症患者的呼吸道症状和头痛.
- 服用免疫抑制药物的多发性硬化患者可能会从COVID-19疫苗接种中获得额外的好处,特别是关于呼吸系统症状.
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