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在发育原始体期间暴露于高水平的葡萄皮质激素会改变成年期对急性压力的转录反应

Min-Kyeung Choi¹, Alexander Cook², Kanak Mungikar²

¹Living Systems Institute & Department of Clinical and Biomedical Sciences, University of Exeter, Stocker Road, EX4 4QD Exeter, UK.

|July 11, 2024

概括

早期生活压力 (ELS) 可以通过发育性葡萄皮质激素 (GC) 暴露改变成年人的行为. 这项研究确定了斑马鱼大脑中的特定基因和表观遗传变化,揭示了与精神疾病相关的hdGC暴露的分子标.

科学领域:

神经科学是一个神经科学.
内分泌学在内分泌学.
遗传学遗传学是一种遗传学.
精神病学是一个精神病学.

背景情况:

早期生活压力 (ELS) 是精神疾病的重要风险因素.
葡萄糖皮质类药物 (GCs) 调解了ELS对成年表型的影响.
高水平的发育性GC (hdGC) 暴露可能为改变成人的反应引发分子变化,但尚未完全了解向分子.

研究的目的:

研究hdGC暴露的终身分子后果.
为了确定分子点,调解hdGC暴露对成年人反应的影响.
探索HDGC诱导的分子变化与人类精神疾病之间的潜在联系.

主要方法:

开发一种新的斑马鱼双击压力模型.
分析hdGC暴露和急性压力后成年鱼大脑中的基因表达变化.
鉴定改变的表观遗传调节元素.

主要成果:

斑马鱼模型在成年时表现出改变的行为和压力过敏.
一组原始基因在暴露于hdGC的成年鱼脑中,特别是在急性压力时表现出改变的表达.
这一基因组富含了人类精神疾病风险因素.
在hdGC暴露后发现了改变的表观遗传调节元件.

结论:

在发育过程中暴露于高水平的葡萄皮质激素会诱导大脑的持久分子变化.
这些变化决定了成年人对压力的特定基因表达反应.
鉴定出的分子标和表观遗传变化为我们提供了关于将早期生活压力与成人精神病风险联系起来的机制的见解.

关键词:

行为神经科学行为神经科学分子神经科学分子神经科学神经科学是一个神经科学.俄米克斯 (Omics) 是一个电子游戏.文字转录学 (Transcriptomics) 是一个学科.

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