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感染HPV-18的同时感染是否会增加HPV-16患者宫病理的风险?

Mustafa Gökkaya¹, Aysun Alcı¹, Okan Aytekin²

¹Department of Gynecological Oncology, Antalya Training and Research Hospital, Health Science University, Antalya, Turkey.

Cytopathology : official journal of the British Society for Clinical Cytology

|July 11, 2024

概括

这项研究发现,在HPV-16单一感染和HPV-16/18联合感染之间,宫发育不良或癌症没有显著差异. 需要进一步的研究来证实这些关于与HPV相关的宫病理的发现.

科学领域:

妇科瘤学妇科瘤学
病毒学病毒学
病理学病理学病理学

背景情况:

人类乳头瘤病毒 (HPV) 类型16和18是导致子宫癌的主要驱动因素.
了解HPV-16单一感染与HPV-16/18联合感染的不同和重叠作用对于风险分层和管理至关重要.

研究的目的:

为了比较患有HPV-16单一感染的妇女和患有HPV-16/18联合感染的妇女之间宫发育不良和侵袭性癌症的患病率和严重程度.

主要方法:

一项多中心的回顾性研究包括736名HPV-16或HPV-16/18阳性妇女接受了结肠镜检查.
患者被分为1组 (HPV-16阳性) 和2组 (HPV-16/18阳性).
CIN2+病变通过结肠镜活检和宫内切除 (ECC) 进行评估,但不包括先前的治疗或其他HPV类型.

主要成果:

总体而言,42.4%的患者被诊断出CIN2+病变.
在HPV-16单一感染和HPV-16/18联合感染组之间没有观察到异常细胞学或CIN2+诊断的显著差异 (p=0.19).
此外,ECC结果也显示两组之间没有显著差异 (p=0.052).

结论:

该研究发现,HPV-16单一感染和HPV-16/18联合感染之间的宫病理没有统计学上显著的差异.
需要进行更大的前性研究来验证这些发现,并探索疾病进展中的潜在细微差别.

关键词:

在HPV-16.在HPV-18中,宫内皮质瘤的发生.科尔波斯科比 (colposcopy) 是一种对体检的方法.同时感染的同时感染.

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