组织工程植入物用于复发性喉神经损伤的直喉切除术重建
Troy Wesson1, Lujuan Zhang1, Rachel A Morrison2
1Department of Otolaryngology-Head and Neck Surgery, Indiana University School of Medicine, Indianapolis, Indiana, U.S.A.
The Laryngoscope
|July 11, 2024
概括
这项研究展示了一种使用原聚合物重建喉癌症手术和复发性喉神经 (RLN) 截切后的新型3种植入物方法,恢复声功能.
科学领域:
- 再生医学是一种再生医学.
- 生物材料科学 生物材料科学
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
背景情况:
- 喉癌手术往往需要循环喉神经 (RLN) 的牺牲,导致严重的声音损伤.
- 目前的重建方案无法在切除后可靠地恢复喉功能.
- 有必要制定有效的喉重建策略.
研究的目的:
- 评估一种新的三种植入物方法,用于用基于原的粘膜,肌肉和软骨替代物进行喉重建.
- 评估这种重建的功能和组织学结果,在猪模型中用RLN切口进行全喉切除术.
- 研究将治疗细胞纳入植入物的潜在好处.
主要方法:
- 六个尤卡坦迷你猪经历了RLN切口的脑喉切除术,并通过制造的原聚合物植入物进行了跨壁重建.
- 动物的子组接受了含有运动末端表达肌肉原生细胞 (MEE) 和/或脂肪干细胞 (ASC) 衍生的状细胞样细胞的植入物.
- 功能评估包括声学发声和喉电肌图 (L-EMG); 组织病理学分析了组织反应.
主要成果:
- 在6只猪中,有5只幸存下来,体重增加,呼吸道维持和听觉声声,不需要气管或食管.
- 组织学分析证实了植入物集成和喉组织 (粘膜,肌肉,软骨) 的再生重塑,没有不良反应.
- 从语音分析和L-EMG获得的早期功能数据表明,对于喉功能恢复有希望的结果.
结论:
- 用于粘膜,肌肉和软骨的原聚合物植入物显示出在用RLN切割进行全喉切除术后有效恢复喉功能的潜力.
- 这种再生方法为由于喉癌手术导致严重功能障碍的患者提供了有希望的解决方案.
- 需要进一步的临床前研究来评估长期的功能结果.
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