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针对M2巨细胞的消耗:与癌症免疫疗法有关

Talia Festekdjian¹, Benjamin Bonavida²

¹Department of Microbiology, Immunology & Molecular Genetics, David Geffen School of Medicine, Jonsson Comprehensive Cancer Center, University of California at Los Angeles, Los Angeles, CA 90095, USA.

Critical reviews in oncogenesis

|July 11, 2024

概括

向瘤相关巨细胞 (TAMs) 是一个有前途的免疫疗法策略,用于增强具有挑战性的癌症中的抗瘤免疫力. 削弱TAM显示出抑制瘤生长和转移的潜力,目前正在进行的临床试验正在调查各种方法.

科学领域:

免疫学免疫学免疫学
在瘤学瘤学.
癌症微环境研究研究

背景情况:

免疫疗法已经在治疗各种癌症方面取得了成功,特别是那些对化疗耐药的癌症.
瘤微环境 (TME) 通常会抑制抗瘤免疫反应.
瘤相关巨细胞 (TAMs) 是TME内的关键免疫细胞,其高频率与患者预后不佳有关.

研究的目的:

在免疫抑制瘤中探索新策略来增强抗瘤免疫反应.
审查针对TAMs恢复抗瘤免疫力和抑制癌症进展的方法.
讨论TAM耗尽方法及其临床相关性.

主要方法:

审查各种TAM耗尽策略,包括微RNA和转录因子 (例如PPARγ,KLF4,STAT3,STAT6,NF-κB).
讨论向化基因/受体和对CSF-1/CSF-1R通路的抗体介导阻断.
探索基于纳米技术的方法和TAM准的组合治疗方法.

主要成果:

已经开发和报告了多种用于TAM耗尽的方法.
临床试验正在积极调查针对TAMs的有效性.
与TAM准策略相关的潜在副作用需要仔细监测和缓解.

结论:

向TAM是一种重要的策略,可以提高免疫治疗对各种癌症的疗效.
进一步的研究和临床评估是必要的,以优化TAM向治疗和管理副作用.
未来的展望重点是改进这些方法以改善抗瘤结果.

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