在癌症免疫治疗中,M2瘤相关巨细胞 (TAMs) 的极化

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Updated: Jun 21, 2025

Macrophage Differentiation and Polarization into an M2-Like Phenotype using a Human Monocyte-Like THP-1 Leukemia Cell Line

Macrophage Differentiation and Polarization into an M2-Like Phenotype using a Human Monocyte-Like THP-1 Leukemia Cell Line

Published on: August 2, 2021

Indy Bui¹, Benjamin Bonavida²

¹University of California Los Angeles.

Critical reviews in oncogenesis

|July 11, 2024

概括

免疫疗法对抗性癌症有希望,但与瘤相关的巨细胞 (TAMs) 阻碍了有效性. 将M2 TAMs定位为M1两极化可能会恢复抗瘤免疫力.

科学领域:

在瘤学瘤学.
免疫学免疫学免疫学
癌症研究癌症研究

背景情况:

最近的免疫疗法进展在某些癌症中提供了持久的反应.
与瘤相关的巨细胞 (TAMs) 创造了一个免疫抑制的瘤微环境,推动癌症的免疫逃避.
了解和准TAM对于克服免疫疗法耐药性至关重要.

研究的目的:

审查M1和M2TAM表型及其在癌症免疫中的作用.
探索调节TAM极化的分子通路.
讨论将M2 TAM偏向M1表型的治疗策略.

主要方法:

关于TAM两极化和免疫治疗耐药性的文献综述.
对参与M1/M2巨分化的信号通路的分析.
检查针对TAM两极分化的治疗剂.

主要成果:

M2 TAMs具有免疫抑制作用,而M1 TAMs则促进抗瘤反应.
基因组脱乙酶抑制剂,PI3K抑制剂,STAT3抑制剂,TLR激动剂和代谢重编程是关键策略.
癌症类型和异质性影响单剂方法的疗效.

结论:

将M2 TAM定位为M1两极化是一种有前途的策略,可以提高免疫治疗的疗效.
由于癌症异质性,可能需要组合疗法.
对量身定制的治疗方法进行进一步研究是有必要的.

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