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Updated: Jun 21, 2025

Yeast As a Chassis for Developing Functional Assays to Study Human P53
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Yeast As a Chassis for Developing Functional Assays to Study Human P53

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直接抑制MYC功能,使用新型基替代基衍生物诱导蛋白质降解并扰乱MYC/MAX相互作用

Can Zhao1, Fang Zhao1, Liuqing Yang1

  • 1School of Pharmacy, Anhui University of Chinese Medicine, Hefei 230012, China.

Journal of medicinal chemistry
|July 11, 2024
PubMed
概括

研究人员开发了针对MYC瘤基因的新型化合物,这是一个具有挑战性的癌症标. 化合物37有效降解MYC,抑制其功能,并在临床前模型中显示出优越的抗癌疗效.

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