在绝经后的韩国妇女中进行激素替代疗法和心肌梗塞和中风
Jin Kyung Baek1, Hee Yon Kim1, Min Jin Kang2
1Department of Obstetrics and Gynecology, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.
概括
在绝经后的韩国女性中,使用激素替代疗法 (HRT) 与心肌梗塞 (MI) 和中风风险降低有关. 在较年轻时开始HRT,特别是使用特定类型的激素治疗 (如tibolone,雌激素-孕激素治疗 (EPT) 或雌激素治疗 (ET),显示出更大的益处.
科学领域:
- 心血管健康 心血管健康
- 内分泌学 在内分泌学.
- 公共卫生 公共卫生
背景情况:
- 更年期与心血管疾病风险增加有关.
- 激素替代疗法 (HRT) 用于管理更年期症状.
- 亚洲人群中HRT类型,持续时间和开始年龄对心血管结果的具体影响需要进一步研究.
研究的目的:
- 调查激素替代疗法 (HRT) 的使用,类型,持续时间和开始年龄与绝经后韩国妇女的心肌梗塞 (MI) 和中风的相关性.
主要方法:
- 使用国家医疗保险服务数据库进行了嵌套病例控制研究.
- 分析了356160名年龄≥50岁的绝经后韩国妇女,这些妇女在2004-2007年间被诊断出患有这种疾病.
- 36,446名HRT使用者 (≥1年) 与不使用者的1:1匹配,按HRT类型和持续时间分类.
主要成果:
- 在50多岁开始使用雌激素-孕激素疗法 (EPT) 或雌激素疗法 (ET),或在60多岁开始使用EPT或提博,与降低中风风险有关.
- 心肌梗塞 (MI) 风险在使用tibolone (任何持续时间) 或EPT/ET使用1-3年后降低.
- 与非使用者相比,在使用tibolone (≥5年) 或EPT/ET使用 (1-3年或≥5年) 时观察到中风风险降低.
结论:
- 特别是在较年轻时开始使用HRT,可能会在绝经后的韩国女性中为MI和中风提供相对的好处.
- 具体的HRT类型和持续时间显示了不同程度的心血管风险降低.
- 研究结果支持HRT在心血管健康方面的潜在有益作用.
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