脑质瘤老年患者生存的危险因素和预测性诺摩图
Zhi-Cheng Fan1, Wen-Jian Zhao1, Yang Jiao1
1Department of Neurosurgery, Tangdu Hospital, Fourth Military Medical University, Xi'an, 710038, China.
Current medical science
|July 11, 2024
概括
这项研究确定了预测老年质瘤患者存活率的关键因素,开发了帮助临床决策和风险分层来改善患者的临床结果.
科学领域:
- 神经瘤学神经瘤学
- 老年医学 老年医学
- 生物统计学 生物统计学
背景情况:
- 大脑质瘤是老年人群的重大健康问题.
- 准确的预后工具对于治疗脑质瘤的老年患者至关重要.
研究的目的:
- 确定老年人 (≥65岁) 脑质瘤生存的独立预后因素.
- 开发和验证总生存率 (OS) 和癌症特异性生存率 (CSS) 的预测性名谱.
主要方法:
- 利用了来自监测,流行病学和最终结果 (SEER) 数据库的大型老年质瘤患者队列的数据.
- 使用LASSO和多变量考克斯回归来确定预后因素.
- 使用内部和外部数据集验证名录,通过C指数,ROC曲线,校准图和决策曲线分析 (DCA) 评估性能.
主要成果:
- 确定了六个独立的预后因素:年龄,婚姻状况,组织学类型,阶段,治疗和瘤位置 (对于CSS).
- 开发了预测6个,12个和24个月生存概率的诺莫格拉姆模型.
- 开发的模型在验证队列中显示出强大的预测性能.
结论:
- 开发的诺基图是对老年质瘤患者的预后评估有价值的工具.
- 这些工具可以帮助临床医生对这一群体进行风险分层和明智的临床决策.
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