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对用酸 (大米片) 中毒的老鼠Lugol溶液的保护作用的评估

Zeinab Vafaeipour¹, Mohsen Imenshahidi^1,2, Amir Hooshang Mohammadpour³

¹Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, 9177948954, Iran.

Cardiovascular toxicology

|July 11, 2024

概括

卢戈尔溶液通过减少组织损伤和氧化应激,对酸 (AlP) 中毒产生保护作用. 这项研究研究了它在减轻大鼠氨酸气 (PH3) 毒性的有效性.

科学领域:

毒理学毒理学毒理学
药理学药理学是指药理学的学科.
生物化学生物化学

背景情况:

米片中的化 (AlP) 是由于素气 (PH3) 释放而引起的中毒的常见原因.
氨酸气毒性呈现出严重的症状,包括心脏休克和低血压.
已知化合物会与素气体发生反应.

研究的目的:

调查Lugol溶液对酸 (AlP) 中毒的保护作用.
为了评估Lugol溶液对素气 (PH3) 毒性标记物的影响.
评估Lugol溶液在减少器官损伤和氧化应激方面的有效性.

主要方法:

在老鼠中确定了ALP的致死剂量 (LD50).
向不同的老鼠群体 (包括对照群) 施用AlP和Lugol溶液.
监测血压,心电图 (ECG),并进行生化和病理学分析.

主要成果:

在被AlP中毒的老鼠中,Lugol溶液显著降低了ECG中的PR间隔和LDH,肌素,ALP和电解质 (Ca2+,Mg2+,K+) 的水平.
降低了甲水平和增加了酶活性,表明氧化应激降低.
组织病理学检查显示,肺部,脏,大脑和心脏的组织完整性得到改善.

结论:

卢戈尔溶液在老鼠中显示出对化中毒的显著保护作用.
保护机制很可能是由于Lugol与素气 (PH3) 的直接反应,从而降低了系统性毒性.
卢戈尔溶液可能是素气中毒的潜在治疗剂.

关键词:

这是一种AlP中毒.对于 AlP 的治疗方法.化的化是一种化.在Lugol Lugol中使用.PH3 毒性的毒性

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